Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients
Amorini, Angela M, Petzold, Axel, Tavazzi, Barbara, Eikelenboom, Judith, Keir, Geoffrey, Belli, Antonio, Giovannoni, Gavin, Di Pietro, Valentina, Polman, Chris, D'Urso, Serafina, Vagnozzi, Roberto, Uitdehaag, Bernard and Lazzarino, Giuseppe (2009) Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients. Clinical Biochemistry, 42, (10-11), 1001-1006. (doi:10.1016/j.clinbiochem.2009.03.020). (PMID:19341721).
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Differently from what previously reported, we here demonstrate that all purine compounds, including uric acid, are elevated in biological fluids of MS patients. Reinforced by the trend observed for creatinine, this corroborates the notion of sustained purine catabolism, possibly due to imbalance in ATP homeostasis, under these pathological conditions. These results cast doubt on the hypothesis that uric acid is depleted in MS because of increased oxidative stress, rather suggesting that this disease causes a generalized increase in purine catabolism. As observed in other pathological states, uric acid, purine compounds and creatinine, can be considered markers of metabolic energy imbalance rather than of reactive oxygen species, even in MS.
|Digital Object Identifier (DOI):||doi:10.1016/j.clinbiochem.2009.03.020|
|Subjects:||R Medicine > R Medicine (General)
T Technology > T Technology (General)
|Divisions :||Faculty of Medicine > Clinical and Experimental Sciences
|Accepted Date and Publication Date:||
|Date Deposited:||13 Oct 2011 09:28|
|Last Modified:||31 Mar 2016 13:45|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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