Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols
Lamberto, M., Corbett, D. F. and Kilburn, J. D. (2003) Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols. Tetrahedron Letters, 44, (7), 1347-1349. (doi:10.1016/S0040-4039(02)02888-5).
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Description/Abstract
Alkenyl and alkynyl isocyanides were synthesised and then reacted, using microwave flash-heating technology, with thiophenol, 2-mercaptoethanol and ethanethiol, in the presence of a radical initiator, to give highly functionalised pyrrolines and pyroglutamates. Direct comparison with results obtained using traditional heating techniques showed the advantage of using the microwave technology in terms of faster reactions and better yields.
| Item Type: | Article |
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| Related URLs: | |
| Keywords: | cyclization |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 20005 |
| Date Deposited: | 20 Feb 2006 |
| Last Modified: | 01 Jun 2011 11:04 |
| Contributors: | Lamberto, M. (Author) Corbett, D. F. (Author) Kilburn, J. D. (Author) |
| Date: | 10 February 2003 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/20005 |
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