Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols


Lamberto, M., Corbett, D. F. and Kilburn, J. D. (2003) Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols. Tetrahedron Letters, 44, (7), 1347-1349. (doi:10.1016/S0040-4039(02)02888-5).

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Description/Abstract

Alkenyl and alkynyl isocyanides were synthesised and then reacted, using microwave flash-heating technology, with thiophenol, 2-mercaptoethanol and ethanethiol, in the presence of a radical initiator, to give highly functionalised pyrrolines and pyroglutamates. Direct comparison with results obtained using traditional heating techniques showed the advantage of using the microwave technology in terms of faster reactions and better yields.

Item Type: Article
Related URLs:
Keywords: cyclization
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 20005
Date Deposited: 20 Feb 2006
Last Modified: 27 Mar 2014 18:09
URI: http://eprints.soton.ac.uk/id/eprint/20005

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