Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers
Lebreton, S., How, S. E., Buchholz, M., Yingyongnarongkul, B. E. and Bradley, M. (2003) Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers. Tetrahedron, 59, (22), 3945-3953. (doi:10.1016/S0040-4020(03)00463-0).
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Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetrical AB(3) isocyanate-type monomers is reported and used for the preparation of tri-branched dendrimers on the solid-phase. This method not only allows isolable dendrimer but can generate high-loading supports and devices for multivalent presentation.
|Keywords:||solid-phase chemistry, dendrimers, high-loading, multivalency, isocyanatehigh-loading resin, peptide-synthesis, beads, chemistry|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||17 Feb 2006|
|Last Modified:||27 Mar 2014 18:09|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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