Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers


Lebreton, S., How, S. E., Buchholz, M., Yingyongnarongkul, B. E. and Bradley, M. (2003) Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers. Tetrahedron, 59, (22), 3945-3953. (doi:10.1016/S0040-4020(03)00463-0).

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Description/Abstract

Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetrical AB(3) isocyanate-type monomers is reported and used for the preparation of tri-branched dendrimers on the solid-phase. This method not only allows isolable dendrimer but can generate high-loading supports and devices for multivalent presentation.

Item Type: Article
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Keywords: solid-phase chemistry, dendrimers, high-loading, multivalency, isocyanatehigh-loading resin, peptide-synthesis, beads, chemistry
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 20008
Date Deposited: 17 Feb 2006
Last Modified: 27 Mar 2014 18:09
URI: http://eprints.soton.ac.uk/id/eprint/20008

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