Antibacterial single-bead screening


Lebreton, S., Newcombe, N. and Bradley, M. (2003) Antibacterial single-bead screening. Tetrahedron, 59, (51), 10213-10222. (doi:10.1016/j.tet.2003.10.070).

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Description/Abstract

Triazine based antibiotics were prepared by the attachment of cyanuric chloride onto a Marshall-type safety catch linker, followed by successive aromatic nucleophilic substitutions, linker activation and nucleophilic cleavage. High-loading dendrimer beads allowed the release of sufficient amount of compound from a single bead to give clear inhibition.

Item Type: Article
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Keywords: beads, dendrimers, triazines, antibiotic, linker solid-phase synthesis, combinatorial libraries, hydroformylationreactions, dendrimer synthesis, substitution, catalysis, chemistry, linkers, monomer, ligands
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 20009
Date Deposited: 17 Feb 2006
Last Modified: 27 Mar 2014 18:09
URI: http://eprints.soton.ac.uk/id/eprint/20009

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