The University of Southampton
University of Southampton Institutional Repository

Antibacterial single-bead screening

Antibacterial single-bead screening
Antibacterial single-bead screening
Triazine based antibiotics were prepared by the attachment of cyanuric chloride onto a Marshall-type safety catch linker, followed by successive aromatic nucleophilic substitutions, linker activation and nucleophilic cleavage. High-loading dendrimer beads allowed the release of sufficient amount of compound from a single bead to give clear inhibition.
beads, dendrimers, triazines, antibiotic, linker solid-phase synthesis, combinatorial libraries, hydroformylationreactions, dendrimer synthesis, substitution, catalysis, chemistry, linkers, monomer, ligands
0040-4020
10213-10222
Lebreton, S.
565a2f7b-c948-4c19-a7d5-704413341ef2
Newcombe, N.
6ad9f57f-b246-4774-b5fa-8c31978c7afa
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
Lebreton, S.
565a2f7b-c948-4c19-a7d5-704413341ef2
Newcombe, N.
6ad9f57f-b246-4774-b5fa-8c31978c7afa
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d

Lebreton, S., Newcombe, N. and Bradley, M. (2003) Antibacterial single-bead screening. Tetrahedron, 59 (51), 10213-10222. (doi:10.1016/j.tet.2003.10.070).

Record type: Article

Abstract

Triazine based antibiotics were prepared by the attachment of cyanuric chloride onto a Marshall-type safety catch linker, followed by successive aromatic nucleophilic substitutions, linker activation and nucleophilic cleavage. High-loading dendrimer beads allowed the release of sufficient amount of compound from a single bead to give clear inhibition.

This record has no associated files available for download.

More information

Published date: 15 December 2003
Keywords: beads, dendrimers, triazines, antibiotic, linker solid-phase synthesis, combinatorial libraries, hydroformylationreactions, dendrimer synthesis, substitution, catalysis, chemistry, linkers, monomer, ligands

Identifiers

Local EPrints ID: 20009
URI: http://eprints.soton.ac.uk/id/eprint/20009
ISSN: 0040-4020
PURE UUID: 535e68e2-37e5-437c-a1c0-57da7799ad4b

Catalogue record

Date deposited: 17 Feb 2006
Last modified: 15 Mar 2024 06:21

Export record

Altmetrics

Contributors

Author: S. Lebreton
Author: N. Newcombe
Author: M. Bradley

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×