Antibacterial single-bead screening
Lebreton, S., Newcombe, N. and Bradley, M. (2003) Antibacterial single-bead screening. Tetrahedron, 59, (51), 10213-10222. (doi:10.1016/j.tet.2003.10.070).
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Original Publication URL: http://dx.doi.org/10.1016/j.tet.2003.10.070
Description/Abstract
Triazine based antibiotics were prepared by the attachment of cyanuric chloride onto a Marshall-type safety catch linker, followed by successive aromatic nucleophilic substitutions, linker activation and nucleophilic cleavage. High-loading dendrimer beads allowed the release of sufficient amount of compound from a single bead to give clear inhibition.
| Item Type: | Article |
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| Related URLs: | |
| Keywords: | beads, dendrimers, triazines, antibiotic, linker solid-phase synthesis, combinatorial libraries, hydroformylationreactions, dendrimer synthesis, substitution, catalysis, chemistry, linkers, monomer, ligands |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 20009 |
| Date Deposited: | 17 Feb 2006 |
| Last Modified: | 31 May 2011 23:30 |
| Contributors: | Lebreton, S. (Author) Newcombe, N. (Author) Bradley, M. (Author) |
| Date: | 15 December 2003 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/20009 |
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