Antibacterial single-bead screening
Lebreton, S., Newcombe, N. and Bradley, M. (2003) Antibacterial single-bead screening. Tetrahedron, 59, (51), 10213-10222. (doi:10.1016/j.tet.2003.10.070).
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Triazine based antibiotics were prepared by the attachment of cyanuric chloride onto a Marshall-type safety catch linker, followed by successive aromatic nucleophilic substitutions, linker activation and nucleophilic cleavage. High-loading dendrimer beads allowed the release of sufficient amount of compound from a single bead to give clear inhibition.
|Keywords:||beads, dendrimers, triazines, antibiotic, linker solid-phase synthesis, combinatorial libraries, hydroformylationreactions, dendrimer synthesis, substitution, catalysis, chemistry, linkers, monomer, ligands|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||17 Feb 2006|
|Last Modified:||31 May 2011 23:30|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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