PLP-dependent enzymes as potential drug targets for protozoan diseases
PLP-dependent enzymes as potential drug targets for protozoan diseases
The chemical properties of the B(6) vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B(6) dependent enzymatic reactions as drug targets. Several current targets are described that are found amongst these enzymes. The focus is set on diseases caused by protozoan parasites. Comparison across a range of these organisms allows insight into the distribution of potential targets, many of which may be of interest in the development of broad range anti-protozoan drugs. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.
serine hydroxymethyltransferase, aspartate transaminase, cysteine desulfurase, ornithine decarboxylase, cysteine synthase, antiprotozoan therapy
1567-1576
Kappes, Barbara
10edf779-dc81-4973-878b-d3177273f86a
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Binter, Alexandra
fc23b5c9-6f9a-470b-9a4e-cb6ff21ac928
Macheroux, Peter
e1c49266-c971-42f7-86ae-394bd128d040
November 2011
Kappes, Barbara
10edf779-dc81-4973-878b-d3177273f86a
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Binter, Alexandra
fc23b5c9-6f9a-470b-9a4e-cb6ff21ac928
Macheroux, Peter
e1c49266-c971-42f7-86ae-394bd128d040
Kappes, Barbara, Tews, Ivo, Binter, Alexandra and Macheroux, Peter
(2011)
PLP-dependent enzymes as potential drug targets for protozoan diseases.
[in special issue: Pyridoxal Phosphate Enzymology]
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1814 (11), .
(doi:10.1016/j.bbapap.2011.07.018).
(PMID:21884827)
Abstract
The chemical properties of the B(6) vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B(6) dependent enzymatic reactions as drug targets. Several current targets are described that are found amongst these enzymes. The focus is set on diseases caused by protozoan parasites. Comparison across a range of these organisms allows insight into the distribution of potential targets, many of which may be of interest in the development of broad range anti-protozoan drugs. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.
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e-pub ahead of print date: 24 July 2011
Published date: November 2011
Keywords:
serine hydroxymethyltransferase, aspartate transaminase, cysteine desulfurase, ornithine decarboxylase, cysteine synthase, antiprotozoan therapy
Organisations:
Centre for Environmental Science
Identifiers
Local EPrints ID: 200215
URI: http://eprints.soton.ac.uk/id/eprint/200215
ISSN: 1570-9639
PURE UUID: 5783441a-20a6-4981-8666-336dab66346c
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Date deposited: 24 Oct 2011 11:09
Last modified: 15 Mar 2024 03:36
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Author:
Barbara Kappes
Author:
Alexandra Binter
Author:
Peter Macheroux
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