Pyridoxal phosphate: biosynthesis and catabolism

Mukherjee, Tathagata, Hanes, Jeremiah, Tews, Ivo, Ealick, Steven E. and Begley, Tadhg P. (2011) Pyridoxal phosphate: biosynthesis and catabolism. [in special issue: Pyridoxal Phosphate Enzymology] Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1814, (11), 1585-1596. (doi:10.1016/j.bbapap.2011.06.018). (PMID:21767669).

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Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a singlet oxygen scavenger and has protective effects against oxidative stress in fungi. Enzymes utilizing vitamin B(6) are important targets for therapeutic agents. This review provides a concise overview of the mechanistic enzymology of vitamin B(6) biosynthesis and catabolism. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.bbapap.2011.06.018
ISSNs: 1570-9639 (print)
Keywords: plp, vitamin B6, dxp dependent pathway, R5P pathway, vitamin B6 catabolism
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Divisions : Faculty of Natural and Environmental Sciences > Biological Sciences
ePrint ID: 200223
Accepted Date and Publication Date:
November 2011Published
8 July 2011Made publicly available
Date Deposited: 24 Oct 2011 11:21
Last Modified: 31 Mar 2016 13:45

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