Pyridoxal phosphate: biosynthesis and catabolism
Pyridoxal phosphate: biosynthesis and catabolism
Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a singlet oxygen scavenger and has protective effects against oxidative stress in fungi. Enzymes utilizing vitamin B(6) are important targets for therapeutic agents. This review provides a concise overview of the mechanistic enzymology of vitamin B(6) biosynthesis and catabolism. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.
plp, vitamin B6, dxp dependent pathway, R5P pathway, vitamin B6 catabolism
1585-1596
Mukherjee, Tathagata
5a076a66-267d-47a9-8a90-ed0884b40597
Hanes, Jeremiah
a55f53e1-569c-4c18-8bfb-c95ed4330c77
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Ealick, Steven E.
2cf05a29-f393-40a9-be87-06780885291e
Begley, Tadhg P.
7c3f0e44-7190-4ac3-a1df-0b23be54097b
November 2011
Mukherjee, Tathagata
5a076a66-267d-47a9-8a90-ed0884b40597
Hanes, Jeremiah
a55f53e1-569c-4c18-8bfb-c95ed4330c77
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Ealick, Steven E.
2cf05a29-f393-40a9-be87-06780885291e
Begley, Tadhg P.
7c3f0e44-7190-4ac3-a1df-0b23be54097b
Mukherjee, Tathagata, Hanes, Jeremiah, Tews, Ivo, Ealick, Steven E. and Begley, Tadhg P.
(2011)
Pyridoxal phosphate: biosynthesis and catabolism.
[in special issue: Pyridoxal Phosphate Enzymology]
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1814 (11), .
(doi:10.1016/j.bbapap.2011.06.018).
(PMID:21767669)
Abstract
Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a singlet oxygen scavenger and has protective effects against oxidative stress in fungi. Enzymes utilizing vitamin B(6) are important targets for therapeutic agents. This review provides a concise overview of the mechanistic enzymology of vitamin B(6) biosynthesis and catabolism. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.
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e-pub ahead of print date: 8 July 2011
Published date: November 2011
Keywords:
plp, vitamin B6, dxp dependent pathway, R5P pathway, vitamin B6 catabolism
Organisations:
Centre for Biological Sciences
Identifiers
Local EPrints ID: 200223
URI: http://eprints.soton.ac.uk/id/eprint/200223
ISSN: 1570-9639
PURE UUID: 22d2d14d-3885-488b-8198-c7a10ee5f43d
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Date deposited: 24 Oct 2011 11:21
Last modified: 15 Mar 2024 03:36
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Contributors
Author:
Tathagata Mukherjee
Author:
Jeremiah Hanes
Author:
Steven E. Ealick
Author:
Tadhg P. Begley
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