Modular three-component solid-phase synthesis of unsymmetrical guanidines via resin capture of carbodiimides

Boguszewski, Paul A., Rahman, Shahzad S. and Ganesan, A. (2004) Modular three-component solid-phase synthesis of unsymmetrical guanidines via resin capture of carbodiimides. Journal of Combinatorial Chemistry, 6 (1), 32-34. (doi:10.1021/cc034036+).

Abstract

Because of their basicity and hydrogen-bonding properties, guanidines are an important functional group in many biologically active compounds of natural or synthetic origin. Consequently, methodologies for the parallel synthesis of guanidines have attracted much attention from both academia and industry. Numerous solid-phase routes have been reported, and the vast majority of these involve either urea or thiourea precursors or guanidine synthesis from pseudoureas or similarly activated amidines.

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