Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology
Clarke, P., Jeffery, M. J., Boydell, A. J., Whiting, S. and Linclau, B. (2004) Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology. Tetrahedron, 60, (16), 3625-3636. (doi:10.1016/j.tet.2004.02.056).
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Tris-1,1,1-(hydroxymethyl)ethane 1 was converted to a series of mono- and disubstituted derivatives. An indirect protocol for the differentiation of the alcohol groups was employed for the synthesis of partially and fully differentiated 1 containing a protected aldehyde unit. Complete differentiation of the alcohol groups was also achieved using a direct strategy (two steps from 1). The first synthesis of 1,3-dialclehydes derived from 1 is reported in two steps.
|Keywords:||scaffold, building block, alcohol differentiation, chemoselective acetal cleavageo-iodoxybenzoic acid, ring-closing metathesis, surfacefunctionalization, pentaerythritol, oxidation, alcohols, diols, derivatives, 1,4-diols, reduction|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||17 Feb 2006|
|Last Modified:||25 Apr 2013 10:50|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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