Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Artigas, María Soler, Loth, Daan W, Wain, Louise V, Gharib, Sina A, Obeidat, Ma'en, Tang, Wenbo, Zhai, Guangju, Zhao, Jing Hua, Smith, Albert Vernon, Huffman, Jennifer E, Albrecht, Eva, Jackson, Catherine M, Evans, David M, Cadby, Gemma, Fornage, Myriam, Manichaikul, Ani, Lopez, Lorna M, Johnson, Toby, Aldrich, Melinda C, Aspelund, Thor, Barroso, Inês, Campbell, Harry, Cassano, Patricia A, Couper, David J, Eiriksdottir, Gudny, Franceschini, Nora, Garcia, Melissa, Gieger, Christian, Gislason, Gauti Kjartan, Grkovic, Ivica, Hammond, Christopher J, Hancock, Dana B, Harris, Tamara B, Ramasamy, Adaikalavan, Heckbert, Susan R, Heliövaara, Markku, Homuth, Georg, Hysi, Pirro G, James, Alan L, Jankovic, Stipan, Joubert, Bonnie R, Karrasch, Stefan, Klopp, Norman, Koch, Beate, Kritchevsky, Stephen B, Launer, Lenore J, Liu, Yongmei, Loehr, Laura R, Lohman, Kurt, Loos, Ruth J F, Lumley, Thomas, Al Balushi, Khalid A, Ang, Wei Q, Barr, R Graham, Beilby, John, Blakey, John D, Boban, Mladen, Boraska, Vesna, Brisman, Jonas, Britton, John R, Brusselle, Guy G, Cooper, Cyrus, Curjuric, Ivan, Dahgam, Santosh, Deary, Ian J, Ebrahim, Shah, Eijgelsheim, Mark, Francks, Clyde, Gaysina, Darya, Granell, Raquel, Gu, Xiangjun, Hankinson, John L, Hardy, Rebecca, Harris, Sarah E, Henderson, John, Henry, Amanda, Hingorani, Aroon D, Hofman, Albert, Holt, Patrick G, Hui, Jennie, Hunter, Michael L, Imboden, Medea, Jameson, Karen A, Kerr, Shona M, Kolcic, Ivana, Kronenberg, Florian, Liu, Jason Z, Marchini, Jonathan, McKeever, Tricia, Morris, Andrew D, Olin, Anna-Carin, Porteous, David J, Postma, Dirkje S, Rich, Stephen S, Ring, Susan M, Rivadeneira, Fernando, Rochat, Thierry, Sayer, Avan Aihie, Sayers, Ian, Sly, Peter D, Smith, George Davey, Sood, Akshay, Starr, John M, Uitterlinden, André G, Vonk, Judith M, Wannamethee, S Goya, Whincup, Peter H, Wijmenga, Cisca, Williams, O Dale, Wong, Andrew, Mangino, Massimo, Marciante, Kristin D, McArdle, Wendy L, Meibohm, Bernd, Morrison, Alanna C, North, Kari E, Omenaas, Ernst, Palmer, Lyle J, Pietiläinen, Kirsi H, Pin, Isabelle, Pola Sbreve Ek, Ozren, Pouta, Anneli, Psaty, Bruce M, Hartikainen, Anna-Liisa, Rantanen, Taina, Ripatti, Samuli, Rotter, Jerome I, Rudan, Igor, Rudnicka, Alicja R, Schulz, Holger, Shin, So-Youn, Spector, Tim D, Surakka, Ida, Vitart, Veronique, Völzke, Henry, Wareham, Nicholas J, Warrington, Nicole M, Wichmann, H-Erich, Wild, Sarah H, Wilk, Jemma B, Wjst, Matthias, Wright, Alan F, Zgaga, Lina, Zemunik, Tatijana, Pennell, Craig E, Nyberg, Fredrik, Kuh, Diana, Holloway, John W, Boezen, H Marike, Lawlor, Debbie A, Morris, Richard W, Probst-Hensch, Nicole, Kaprio, Jaakko, Wilson, James F, Hayward, Caroline, Kähönen, Mika, Heinrich, Joachim, Musk, Arthur W, Jarvis, Deborah L, Gläser, Sven, Järvelin, Marjo-Riitta, Ch Stricker, Bruno H, Elliott, Paul, O'Connor, George T, Strachan, David P, London, Stephanie J, Hall, Ian P, Gudnason, Vilmundur and Tobin, Martin D (2011) Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43, (11), 1082-1090. (doi:10.1038/ng.941). (PMID:21946350).
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Description/Abstract
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10−8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
| Item Type: | Article |
|---|---|
| ISSNs: | 1061-4036 (print) 1546-1718 (electronic) |
| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine > Human Development and Health Faculty of Medicine > Infection, Inflammation and Immunity |
| Item ID: | 202485 |
| Date Deposited: | 07 Dec 2011 14:40 |
| Last Modified: | 19 Jul 2012 11:45 |
| Contributors: | Artigas, María Soler (Author) Loth, Daan W (Author) Wain, Louise V (Author) Gharib, Sina A (Author) Obeidat, Ma'en (Author) Tang, Wenbo (Author) Zhai, Guangju (Author) Zhao, Jing Hua (Author) Smith, Albert Vernon (Author) Huffman, Jennifer E (Author) Albrecht, Eva (Author) Jackson, Catherine M (Author) Evans, David M (Author) Cadby, Gemma (Author) Fornage, Myriam (Author) Manichaikul, Ani (Author) Lopez, Lorna M (Author) Johnson, Toby (Author) Aldrich, Melinda C (Author) Aspelund, Thor (Author) Barroso, Inês (Author) Campbell, Harry (Author) Cassano, Patricia A (Author) Couper, David J (Author) Eiriksdottir, Gudny (Author) Franceschini, Nora (Author) Garcia, Melissa (Author) Gieger, Christian (Author) Gislason, Gauti Kjartan (Author) Grkovic, Ivica (Author) Hammond, Christopher J (Author) Hancock, Dana B (Author) Harris, Tamara B (Author) Ramasamy, Adaikalavan (Author) Heckbert, Susan R (Author) Heliövaara, Markku (Author) Homuth, Georg (Author) Hysi, Pirro G (Author) James, Alan L (Author) Jankovic, Stipan (Author) Joubert, Bonnie R (Author) Karrasch, Stefan (Author) Klopp, Norman (Author) Koch, Beate (Author) Kritchevsky, Stephen B (Author) Launer, Lenore J (Author) Liu, Yongmei (Author) Loehr, Laura R (Author) Lohman, Kurt (Author) Loos, Ruth J F (Author) Lumley, Thomas (Author) Al Balushi, Khalid A (Author) Ang, Wei Q (Author) Barr, R Graham (Author) Beilby, John (Author) Blakey, John D (Author) Boban, Mladen (Author) Boraska, Vesna (Author) Brisman, Jonas (Author) Britton, John R (Author) Brusselle, Guy G (Author) Cooper, Cyrus (Author) Curjuric, Ivan (Author) Dahgam, Santosh (Author) Deary, Ian J (Author) Ebrahim, Shah (Author) Eijgelsheim, Mark (Author) Francks, Clyde (Author) Gaysina, Darya (Author) Granell, Raquel (Author) Gu, Xiangjun (Author) Hankinson, John L (Author) Hardy, Rebecca (Author) Harris, Sarah E (Author) Henderson, John (Author) Henry, Amanda (Author) Hingorani, Aroon D (Author) Hofman, Albert (Author) Holt, Patrick G (Author) Hui, Jennie (Author) Hunter, Michael L (Author) Imboden, Medea (Author) Jameson, Karen A (Author) Kerr, Shona M (Author) Kolcic, Ivana (Author) Kronenberg, Florian (Author) Liu, Jason Z (Author) Marchini, Jonathan (Author) McKeever, Tricia (Author) Morris, Andrew D (Author) Olin, Anna-Carin (Author) Porteous, David J (Author) Postma, Dirkje S (Author) Rich, Stephen S (Author) Ring, Susan M (Author) Rivadeneira, Fernando (Author) Rochat, Thierry (Author) Sayer, Avan Aihie (Author) Sayers, Ian (Author) Sly, Peter D (Author) Smith, George Davey (Author) Sood, Akshay (Author) Starr, John M (Author) Uitterlinden, André G (Author) Vonk, Judith M (Author) Wannamethee, S Goya (Author) Whincup, Peter H (Author) Wijmenga, Cisca (Author) Williams, O Dale (Author) Wong, Andrew (Author) Mangino, Massimo (Author) Marciante, Kristin D (Author) McArdle, Wendy L (Author) Meibohm, Bernd (Author) Morrison, Alanna C (Author) North, Kari E (Author) Omenaas, Ernst (Author) Palmer, Lyle J (Author) Pietiläinen, Kirsi H (Author) Pin, Isabelle (Author) Pola Sbreve Ek, Ozren (Author) Pouta, Anneli (Author) Psaty, Bruce M (Author) Hartikainen, Anna-Liisa (Author) Rantanen, Taina (Author) Ripatti, Samuli (Author) Rotter, Jerome I (Author) Rudan, Igor (Author) Rudnicka, Alicja R (Author) Schulz, Holger (Author) Shin, So-Youn (Author) Spector, Tim D (Author) Surakka, Ida (Author) Vitart, Veronique (Author) Völzke, Henry (Author) Wareham, Nicholas J (Author) Warrington, Nicole M (Author) Wichmann, H-Erich (Author) Wild, Sarah H (Author) Wilk, Jemma B (Author) Wjst, Matthias (Author) Wright, Alan F (Author) Zgaga, Lina (Author) Zemunik, Tatijana (Author) Pennell, Craig E (Author) Nyberg, Fredrik (Author) Kuh, Diana (Author) Holloway, John W (Author) Boezen, H Marike (Author) Lawlor, Debbie A (Author) Morris, Richard W (Author) Probst-Hensch, Nicole (Author) Kaprio, Jaakko (Author) Wilson, James F (Author) Hayward, Caroline (Author) Kähönen, Mika (Author) Heinrich, Joachim (Author) Musk, Arthur W (Author) Jarvis, Deborah L (Author) Gläser, Sven (Author) Järvelin, Marjo-Riitta (Author) Ch Stricker, Bruno H (Author) Elliott, Paul (Author) O'Connor, George T (Author) Strachan, David P (Author) London, Stephanie J (Author) Hall, Ian P (Author) Gudnason, Vilmundur (Author) Tobin, Martin D (Author) |
| Date: | 25 September 2011 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/202485 |
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