Thiol-mediated free radical cyclisations of isocyanides on solid support


Lamberto, M., Corbett, D. F. and Kilburn, J. D. (2004) Thiol-mediated free radical cyclisations of isocyanides on solid support. Tetrahedron Letters, 45, (46), 8541-8543. (doi:10.1016/j.tetlet.2004.09.078).

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Description/Abstract

Three novel polymer-supported isocyanides have been synthesised, from commercial Wang and HMBA-AM resins, and reacted under radical conditions with 2-mercaptoethanol and ethanethiol to give the corresponding pyrrolidine or pyroglutamic acid derivatives in good yields.

Item Type: Article
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Keywords: alkynyl isocyanides, peptide-synthesis, isonitriles, phase, alkenyl, acid, (+/-)-camptothecin, annulations, derivatives, route
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 20261
Date Deposited: 20 Feb 2006
Last Modified: 27 Mar 2014 18:10
URI: http://eprints.soton.ac.uk/id/eprint/20261

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