Thiol-mediated free radical cyclisations of isocyanides on solid support
Lamberto, M., Corbett, D. F. and Kilburn, J. D. (2004) Thiol-mediated free radical cyclisations of isocyanides on solid support. Tetrahedron Letters, 45, (46), 8541-8543. (doi:10.1016/j.tetlet.2004.09.078).
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Original Publication URL: http://dx.doi.org/10.1016/j.tetlet.2004.09.078
Description/Abstract
Three novel polymer-supported isocyanides have been synthesised, from commercial Wang and HMBA-AM resins, and reacted under radical conditions with 2-mercaptoethanol and ethanethiol to give the corresponding pyrrolidine or pyroglutamic acid derivatives in good yields.
| Item Type: | Article |
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| Related URLs: | |
| Keywords: | alkynyl isocyanides, peptide-synthesis, isonitriles, phase, alkenyl, acid, (+/-)-camptothecin, annulations, derivatives, route |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 20261 |
| Date Deposited: | 20 Feb 2006 |
| Last Modified: | 01 Jun 2011 01:50 |
| Contributors: | Lamberto, M. (Author) Corbett, D. F. (Author) Kilburn, J. D. (Author) |
| Date: | 8 November 2004 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/20261 |
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