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Modeling novel radiopharmaceuticals: mono-C6-substituted PnAO ligands (PnAO=3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime)

Modeling novel radiopharmaceuticals: mono-C6-substituted PnAO ligands (PnAO=3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime)
Modeling novel radiopharmaceuticals: mono-C6-substituted PnAO ligands (PnAO=3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime)
The solid-state behavior of six novel 6-substituted PnAO (propylene amine oxime) complexes (6-11) involving Tc(V), Co(III), and Cu(II) salts is reported. Each of the Tc complexes 6-8 has the C6-substituent located equatorially in a six-membered chelate ring involving a Tc = O unit which has the expected boat geometry. The C6-substituent therefore has little effect on the conformational behavior of the PnAO complex and thus provides an attractive site for further modification. The Co(III) complex 9 has the expected octahedral geometry, while the Cu(II) complexes 10 and 11 form square-based pyramids capped by water molecules. One Cu(II) system (10) contains two unique complexes in the asymmetric unit which are associated via multiple hydrogen bonds to a BF4 anion, the remaining BF4 anion being loosely hydrogen bonded to a coordinating water molecule. The cobalt and copper complexes 9-11 each exhibit a chair conformation for the six-membered chelate ring.
molecular hydrogen-bond, crystal-structure, trans-dinitrocobalt(iii) complex, tc-99m complexes, x-ray, coordination, copper(ii), perfusion, spect, ions
0020-1669
4145-4153
Walker, Paul S.
d110682e-e70a-4afa-8042-3ec4f46428c3
Bergin, Paul M.
92afeb56-cf2c-4058-9418-569925ac98d1
Grossel, Martin C.
403bf3ff-6364-44e9-ab46-52d84c6f0d56
Horton, Peter N.
154c8930-bfc3-495b-ad4a-8a278d5da3a5
Walker, Paul S.
d110682e-e70a-4afa-8042-3ec4f46428c3
Bergin, Paul M.
92afeb56-cf2c-4058-9418-569925ac98d1
Grossel, Martin C.
403bf3ff-6364-44e9-ab46-52d84c6f0d56
Horton, Peter N.
154c8930-bfc3-495b-ad4a-8a278d5da3a5

Walker, Paul S., Bergin, Paul M., Grossel, Martin C. and Horton, Peter N. (2004) Modeling novel radiopharmaceuticals: mono-C6-substituted PnAO ligands (PnAO=3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime). Inorganic Chemistry, 43 (14), 4145-4153. (doi:10.1021/ic0497634).

Record type: Article

Abstract

The solid-state behavior of six novel 6-substituted PnAO (propylene amine oxime) complexes (6-11) involving Tc(V), Co(III), and Cu(II) salts is reported. Each of the Tc complexes 6-8 has the C6-substituent located equatorially in a six-membered chelate ring involving a Tc = O unit which has the expected boat geometry. The C6-substituent therefore has little effect on the conformational behavior of the PnAO complex and thus provides an attractive site for further modification. The Co(III) complex 9 has the expected octahedral geometry, while the Cu(II) complexes 10 and 11 form square-based pyramids capped by water molecules. One Cu(II) system (10) contains two unique complexes in the asymmetric unit which are associated via multiple hydrogen bonds to a BF4 anion, the remaining BF4 anion being loosely hydrogen bonded to a coordinating water molecule. The cobalt and copper complexes 9-11 each exhibit a chair conformation for the six-membered chelate ring.

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More information

Submitted date: 23 February 2004
Published date: 12 July 2004
Keywords: molecular hydrogen-bond, crystal-structure, trans-dinitrocobalt(iii) complex, tc-99m complexes, x-ray, coordination, copper(ii), perfusion, spect, ions

Identifiers

Local EPrints ID: 20336
URI: http://eprints.soton.ac.uk/id/eprint/20336
ISSN: 0020-1669
PURE UUID: 51a374d5-efca-40eb-a722-25eef06c8adb
ORCID for Martin C. Grossel: ORCID iD orcid.org/0000-0001-7469-6854
ORCID for Peter N. Horton: ORCID iD orcid.org/0000-0001-8886-2016

Catalogue record

Date deposited: 16 Feb 2006
Last modified: 16 Mar 2024 03:12

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Contributors

Author: Paul S. Walker
Author: Paul M. Bergin
Author: Peter N. Horton ORCID iD

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