The influence of clinicalpathological features on the Predictive accuracy of conventional breast imaging in determining the extent of screen-detected high-grade pure ductal carcinoma in situ


Hayward, L., Oeppen, R.S., Grima, A.V., Royle, G.T., Rubin, C.M. and Cutress, R.I. (2011) The influence of clinicalpathological features on the Predictive accuracy of conventional breast imaging in determining the extent of screen-detected high-grade pure ductal carcinoma in situ. Annals of The Royal College of Surgeons of England, 93, (5), 385-390. (doi:10.1308/003588411X579829). (PMID:21943463).

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Description/Abstract

INTRODUCTION: The extent of calcified ductal carcinoma in situ (DCIS) detected by screening mammography is a determinant for treatment with breast conserving surgery (BCS). However, DCIS may be uncalcified and almost a quarter of patients with DCIS treated initially by BCS either require a second operation or are found to have unexpected invasive disease following surgery. Identification of these cases might guide selective implementation of additional diagnostic procedures.

METHODS: A retrospective review of patients with a preoperative diagnosis of pure high-grade DCIS at the Southampton and Salisbury Breast Screening Unit over a ten-year period was carried out. Mammograms were reviewed independently by a consultant radiologist and additional factors including the Breast Imaging Reporting and Data System (BI-RADS®) breast density score, DCIS extent and disease location within the breast recorded.

RESULTS: Unexpected invasive disease was found in 35 of 144 patients (24%). Within our unit the re-excision rate for all screen-detected DCIS is currently 23% but for patients included in this study with high-grade DCIS the re-excision rate was 39% (34/87). The extent of DCIS (p=0.008) and lack of expression of the oestrogen receptor (ER) predicted the requirement for re-excision in both univariate (p=0.004) and multivariate analysis (p=0.005).

CONCLUSIONS: High-grade DCIS may be focally uncalcified, leading to underestimation of disease extent, which might be related to ER status. Invasive foci associated with high-grade DCIS are often mammographically occult. Exploration of additional biomarkers and targeted use of further diagnostic techniques may improve the preoperative staging of DCIS.

Item Type: Article
ISSNs: 0035-8843 (print)
1478-7083 (electronic)
Keywords: breast, carcinoma in situ, screening, estrogen receptor
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine > Cancer Sciences
ePrint ID: 203361
Date Deposited: 16 Nov 2011 10:32
Last Modified: 27 Mar 2014 19:47
URI: http://eprints.soton.ac.uk/id/eprint/203361

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