EZH2 mutational status predicts poor survival in myelofibrosis
Guglielmelli, P., Biamonte, F., Score, J., Hidalgo-Curtis, C., Cervantes, F., Maffioli, M., Fanelli, T., Ernst, T., Winkelman, N., Jones, A. V., Zoi, K., Reiter, A., Duncombe, A., Villani, L., Bosi, A., Barosi, G., Cross, N. C. P. and Vannucchi, A. M. (2011) EZH2 mutational status predicts poor survival in myelofibrosis. Blood, 118, (19), 5227-5234. (doi:10.1182/blood-2011-06-363424).
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Description/Abstract
We genotyped 370 subjects with primary myelofibrosis (PMF) and 148 with postpolycythemia vera/postessential thrombocythemia (PPV/PET) MF for mutations of EZH2. Mutational status at diagnosis was correlated with hematologic parameters, clinical manifestations, and outcome. A total of 25 different EZH2 mutations were detected in 5.9% of PMF, 1.2% of PPV-MF, and 9.4% of PET-MF patients; most were exonic heterozygous missense changes. EZH2 mutation coexisted with JAK2V617F or ASXL1 mutation in 12 of 29 (41.4%) and 6 of 27 (22.2%) evaluated patients; TET2 and CBL mutations were found in 2 and 1 patients, respectively. EZH2-mutated PMF patients had significantly higher leukocyte counts, blast-cell counts, and larger spleens at diagnosis, and most of them (52.6%) were in the high-risk International Prognostic Score System (IPSS) category. After a median follow-up of 39 months, 128 patients (25.9%) died, 81 (63.3%) because of leukemia. Leukemia-free survival (LFS) and overall survival (OS) were significantly reduced in EZH2-mutated PMF patients (P = .028 and P < .001, respectively); no such impact was seen for PPV/PET-MF patients, possibly due to the low number of mutated cases. In multivariate analysis, survival of PMF patients was predicted by IPSS high-risk category, a < 25% JAK2V617F allele burden, and EZH2 mutation status. We conclude that EZH2 mutations are independently associated with shorter survival in patients with PMF.
| Item Type: | Article |
|---|---|
| ISSNs: | 0006-4971 (print) 1528-0020 (electronic) |
| Related URLs: | |
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Faculty of Medicine > Human Development and Health |
| Item ID: | 204063 |
| Date Deposited: | 23 Nov 2011 12:05 |
| Last Modified: | 01 Jan 2012 08:07 |
| Contributors: | Guglielmelli, P. (Author) Biamonte, F. (Author) Score, J. (Author) Hidalgo-Curtis, C. (Author) Cervantes, F. (Author) Maffioli, M. (Author) Fanelli, T. (Author) Ernst, T. (Author) Winkelman, N. (Author) Jones, A. V. (Author) Zoi, K. (Author) Reiter, A. (Author) Duncombe, A. (Author) Villani, L. (Author) Bosi, A. (Author) Barosi, G. (Author) Cross, N. C. P. (Author) Vannucchi, A. M. (Author) |
| Date: | 10 November 2011 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/204063 |
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