Divergent synthetic approach to 6′′-modified α-GalCer analogues
Pauwels, Nora, Aspeslagh, Sandrine, Vanhoenacker, Gerd, Sandra, Koen, Yu, Esther D., Zajonc, Dirk M., Elewaut, Dirk, Linclau, Bruno and Van Calenbergh, Serge (2011) Divergent synthetic approach to 6′′-modified α-GalCer analogues. Organic & Biomolecular Chemistry, 9, (24), 8413-8421. (doi:10.1039/c1ob06235b).
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Description/Abstract
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6′′-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6′′-modified KRN7000 analogues
| Item Type: | Article |
|---|---|
| ISSNs: | 1477-0520 (print) 1477-0539 (electronic) |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Natural and Environmental Sciences > Chemistry |
| Item ID: | 205381 |
| Date Deposited: | 07 Dec 2011 09:08 |
| Last Modified: | 15 Jun 2012 09:09 |
| Contributors: | Pauwels, Nora (Author) Aspeslagh, Sandrine (Author) Vanhoenacker, Gerd (Author) Sandra, Koen (Author) Yu, Esther D. (Author) Zajonc, Dirk M. (Author) Elewaut, Dirk (Author) Linclau, Bruno (Author) Van Calenbergh, Serge (Author) |
| Date: | September 2011 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/205381 |
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