Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
Zhang, Ya, Zhang, Weikai, Johnston, Alexander H., Newman, Tracey .A., Pyykko, Ilmari and Zou, Jing (2011) Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve. International Journal of Nanomedicine (PMID:22403485).
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Polymersomes are nano-sized vesicles formed from amphiphilic block copolymers that have been identified as potential drug delivery vehicles to the inner ear. The aim of this study is to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the GT1b receptor on neurons and is expected to target the polymersomes towards the cochlear nerve. The Tet1 functionalized PEG-b-PCL PMs were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.
|Subjects:||Q Science > QH Natural history > QH301 Biology
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
|Divisions:||Faculty of Medicine
|Date Deposited:||07 Dec 2011 14:51|
|Last Modified:||31 Mar 2016 13:47|
3g-Nanotechnology based targeted drug delivery using the inner ear as a model target organ (NANOEAR)
Funded by: European Commission - FP6 (26556)
1 November 2006 to 31 October 2011
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