CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides
CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides
3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one were synthesised and incorporated directly into triplex-forming oligonucleotides in order to utilise their extended hydrogen bonding motif for recognition of the CG base pair. All analogues demonstrated strong binding affinity and very good selectivity for CG from pH 6.2 to 7.0; a marked improvement on previous modifications.
5087-5096
Gerrard, Simon R.
4ed7b304-42c2-497a-b00d-5ac8a1bedd24
Edrees, Mastoura M.
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Bouamaied, Imenne
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Fox, Keith R.
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Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
6 September 2010
Gerrard, Simon R.
4ed7b304-42c2-497a-b00d-5ac8a1bedd24
Edrees, Mastoura M.
bab73a24-d218-434e-993f-c649df732440
Bouamaied, Imenne
9938a8f5-740f-4c9c-9285-8a16a43a5fe5
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Gerrard, Simon R., Edrees, Mastoura M., Bouamaied, Imenne, Fox, Keith R. and Brown, Tom
(2010)
CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides.
Organic & Biomolecular Chemistry, 8 (22), .
(doi:10.1039/c0ob00119h).
(PMID:20835452)
Abstract
3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one were synthesised and incorporated directly into triplex-forming oligonucleotides in order to utilise their extended hydrogen bonding motif for recognition of the CG base pair. All analogues demonstrated strong binding affinity and very good selectivity for CG from pH 6.2 to 7.0; a marked improvement on previous modifications.
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Published date: 6 September 2010
Organisations:
Molecular and Cellular
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Local EPrints ID: 206541
URI: http://eprints.soton.ac.uk/id/eprint/206541
ISSN: 1477-0520
PURE UUID: 6846c81f-8606-4f75-84cf-7821867549c6
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Date deposited: 22 Dec 2011 15:29
Last modified: 15 Mar 2024 02:36
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Author:
Simon R. Gerrard
Author:
Mastoura M. Edrees
Author:
Imenne Bouamaied
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