CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides


Gerrard, Simon R., Edrees, Mastoura M., Bouamaied, Imenne, Fox, Keith R. and Brown, Tom (2010) CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides. Organic & Biomolecular Chemistry, 8, (22), 5087-5096. (doi:10.1039/c0ob00119h). (PMID:20835452).

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Description/Abstract

3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one were synthesised and incorporated directly into triplex-forming oligonucleotides in order to utilise their extended hydrogen bonding motif for recognition of the CG base pair. All analogues demonstrated strong binding affinity and very good selectivity for CG from pH 6.2 to 7.0; a marked improvement on previous modifications.

Item Type: Article
ISSNs: 1477-0520 (print)
1477-0539 (electronic)
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural and Environmental Sciences > Biological Sciences > Molecular & Cellular
ePrint ID: 206541
Date Deposited: 22 Dec 2011 15:29
Last Modified: 27 Mar 2014 19:49
URI: http://eprints.soton.ac.uk/id/eprint/206541

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