CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides
Gerrard, Simon R., Edrees, Mastoura M., Bouamaied, Imenne, Fox, Keith R. and Brown, Tom (2010) CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides. Organic & Biomolecular Chemistry, 8, (22), 5087-5096. (doi:10.1039/c0ob00119h). (PMID:20835452).
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Description/Abstract
3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one were synthesised and incorporated directly into triplex-forming oligonucleotides in order to utilise their extended hydrogen bonding motif for recognition of the CG base pair. All analogues demonstrated strong binding affinity and very good selectivity for CG from pH 6.2 to 7.0; a marked improvement on previous modifications.
| Item Type: | Article |
|---|---|
| ISSNs: | 1477-0520 (print) 1477-0539 (electronic) |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Natural and Environmental Sciences > Biological Sciences > Molecular & Cellular |
| Item ID: | 206541 |
| Date Deposited: | 22 Dec 2011 15:29 |
| Last Modified: | 22 May 2013 01:27 |
| Contributors: | Gerrard, Simon R. (Author) Edrees, Mastoura M. (Author) Bouamaied, Imenne (Author) Fox, Keith R. (Author) Brown, Tom (Author) |
| Funder: | BBSRC |
| Date: | 6 September 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/206541 |
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