Synthesis of 2-oxazolines mediated by N,N′-diisopropylcarbodiimide
Crosignani, Stefano, Young, Abigail C. and Linclau, Bruno (2004) Synthesis of 2-oxazolines mediated by N,N′-diisopropylcarbodiimide. Tetrahedron Letters, 45, (52), 9611-9615. (doi:10.1016/j.tetlet.2004.10.143).
Download
Full text not available from this repository.
Original Publication URL: http://dx.doi.org/10.1016/j.tetlet.2004.10.143
Description/Abstract
N-(β-Hydroxy)amides can be cyclised by reaction with diisopropylcarbodiimide (DIC) to give the corresponding 2-oxazolines in high yields. The reaction requires only very mild Lewis-acid catalysis (5 mol % Cu(OTf)2) and can be accomplished with simple heating, or in very short reaction times under microwave irradiation.
| Item Type: | Article |
|---|---|
| ISSNs: | 0040-4039 (print) |
| Related URLs: | |
| Keywords: | 2-oxazoline, isourea, lewis acid, microwave irradiation, carbodiimide, microwave irradiation, asymmetric-synthesis, carboxylic-acids, oxazolines, alcohols, conversion, inhibitors, thiazolines, derivatives, release |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 20769 |
| Date Deposited: | 03 Mar 2006 |
| Last Modified: | 01 Jun 2011 01:51 |
| Contributors: | Crosignani, Stefano (Author) Young, Abigail C. (Author) Linclau, Bruno (Author) |
| Date: | 20 December 2004 |
| Status: | Published |
| Contact Email Address: | bruno.linclau@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/20769 |
Actions (login required)
 |
View Item |
