Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: Results from the Salmon in Pregnancy Study


Helmersson-Karlqvist, Johanna, Miles, Elizabeth A., Vlachava, Maria, Kremmyda, Lefkothea-Stella, Noakes , Paul S., Diaper, Norma D., Godfrey, Keith M., Calder, Philip C. and Basu, Samar (2012) Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: Results from the Salmon in Pregnancy Study. Prostaglandins Leukotrienes and Essential Fatty Acids, 86, (1-2), 35-38. (doi:10.1016/j.plefa.2011.10.008). (PMID:22047909).

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Description/Abstract

Oily fishintakeduringpregnancymayreducetheriskofallergicdiseasesininfancypossiblybyshiftsin
the fattyacidbalanceandsubsequentalteredprostaglandin(PG)formation.Thisinterventionisthe
first studytoevaluateifincreasedoilyfishintakeaffects in vivo PGF2a formationduringpregnancy.
Britishpregnantwomenwererandomisedtotwoportionsoffarmedsalmonweekly(n¼47),
or maintenanceoftheirnormaldietlowinfish(n¼41), frompregnancyweek20untilparturition.
The concentrationsofeicosapentaenoicanddocosahexaenoicacidsinplasmaphosphatidylcholine(PC)
were higherandtheconcentrationofarachidonicacidinplasmaPCwaslowerinthesalmongroup
than thecontrolgroupatweeks34and38ofpregnancy.PGF2a formationwasevaluatedbyurinary
measurementof15-keto-dihydro-PGF2a, amajorPGF2a metabolite,at20,34and38weeks.Inboththe
salmon andcontrolgroupsurinary15-keto-dihydro-PGF2a concentrationsincreasedsignificantly
during pregnancy,whichmaybeofphysiologicalimportance.Oilyfishinterventionalteredfattyacid
concentrationsbutdidnotaffecturinary15-keto-dihydro-PGF2a concentrationsinpregnantwomen.

Item Type: Article
ISSNs: 0952-3278 (print)
Related URLs:
Keywords: prostaglandin F2a, pregnancy, salmon, n-3 long chain polyunsaturated fatty acids Allergy COX
Subjects: R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Health Sciences
ePrint ID: 208359
Date Deposited: 19 Jan 2012 10:00
Last Modified: 27 Mar 2014 19:49
URI: http://eprints.soton.ac.uk/id/eprint/208359

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