Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass


Lewis, R.M., Cleal, J.K. and Ntani, G. et al. (2012) Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass. Bone, 50, (1), 337-342. (doi:10.1016/j.bone.2011.11.003). (PMID:22100507).

Download

Full text not available from this repository.

Description/Abstract

Alterations in expression of the imprinted gene PHLDA2 are linked to low birth weight in both humans and the mouse. However birth weight is a summary measure of fetal growth and provides little information on the growth rate of the fetus in early and late pregnancy. To examine the relation of PHLDA2expression with rates of fetal growth and explore associations with the infant's body composition in early childhood, we measured PHLDA2 mRNA levels in the term placenta of 102 infants whose mothers were participating in the Southampton Women's Survey (SWS). Higher PHLDA2expression was associated with a lower fetal femur growth velocity between 19 and 34 weeks gestation. In addition, higher placentalPHLDA2 gene expression was associated with a lower child's bone mineral content at four years of age, measured using dual-energy X-ray absorptiometry. The results suggest that placentalPHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction

Item Type: Article
ISSNs: 8756-3282 (print)
Keywords: phlda2, fetal growth, bone mineral content, imprinted genes, placenta
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QP Physiology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Health Sciences
ePrint ID: 208775
Date Deposited: 23 Jan 2012 12:12
Last Modified: 27 Mar 2014 19:49
URI: http://eprints.soton.ac.uk/id/eprint/208775

Actions (login required)

View Item View Item