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Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo [2,3-d] pyrimidin-2(7H)-one nucleoside analogues

Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo [2,3-d] pyrimidin-2(7H)-one nucleoside analogues
Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo [2,3-d] pyrimidin-2(7H)-one nucleoside analogues
Substituted 3H-pyrrolo[2,3-d] pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.
forming-oligonucleotides, selective recognition, binding motif, base-pairs, sequence
1359-7345
2555-2557
Ranasinghe, Rohan T.
b29fc8b4-2a66-430a-85fa-ff1c9c261f32
Rusling, David A.
d08f1f97-f8a9-4980-a025-ae41c23a938f
Powers, Vicki E.C.
0646d625-5039-454c-a8ad-0da6bc72ae8a
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Ranasinghe, Rohan T.
b29fc8b4-2a66-430a-85fa-ff1c9c261f32
Rusling, David A.
d08f1f97-f8a9-4980-a025-ae41c23a938f
Powers, Vicki E.C.
0646d625-5039-454c-a8ad-0da6bc72ae8a
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89

Ranasinghe, Rohan T., Rusling, David A., Powers, Vicki E.C., Fox, Keith R. and Brown, Tom (2005) Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo [2,3-d] pyrimidin-2(7H)-one nucleoside analogues. Chemical Communications, 20, 2555-2557. (doi:10.1039/b502325d).

Record type: Article

Abstract

Substituted 3H-pyrrolo[2,3-d] pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.

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More information

Published date: 14 April 2005
Keywords: forming-oligonucleotides, selective recognition, binding motif, base-pairs, sequence
Organisations: Centre for Biological Sciences
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Identifiers

Local EPrints ID: 20895
URI: http://eprints.soton.ac.uk/id/eprint/20895
DOI: doi:10.1039/b502325d
ISSN: 1359-7345
PURE UUID: 2d2cba64-8117-4cd2-b188-a98ac4ac13ed
ORCID for David A. Rusling: ORCID iD orcid.org/0000-0002-7442-686X
ORCID for Keith R. Fox: ORCID iD orcid.org/0000-0002-2925-7315

Catalogue record

Date deposited: 02 Mar 2006
Last modified: 16 Mar 2024 02:36

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Contributors

Author: Rohan T. Ranasinghe
Author: David A. Rusling ORCID iD
Author: Vicki E.C. Powers
Author: Keith R. Fox ORCID iD
Author: Tom Brown

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