Long term respiratory consequences of intrauterine growth restriction

Pike, Katharine, Pillow, J. Jane and Lucas, Jane S. (2012) Long term respiratory consequences of intrauterine growth restriction. Seminars in Fetal & Neonatal Medicine, 17, (2), 92-98. (doi:10.1016/j.siny.2012.01.003). (PMID:22277109).


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Epidemiological studies demonstrate that in-utero growth restriction and low birth weight are associated with impaired lung function and increased respiratory morbidity from infancy, throughout childhood and into adulthood. Chronic restriction of nutrients and/or oxygen during late pregnancy causes abnormalities in the airways and lungs of offspring, including smaller numbers of enlarged alveoli with thicker septal walls and basement membranes. The structural abnormalities and impaired lung function seen soon after birth persist or even progress with age. These changes are likely to cause lung symptomology through life and hasten lung aging.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.siny.2012.01.003
ISSNs: 1744-165X (print)
Keywords: adult, fetal, intrauterine growth restriction, lung, lung function, lung maturation
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RG Gynecology and obstetrics
Divisions : Faculty of Medicine > Clinical and Experimental Sciences
ePrint ID: 209395
Accepted Date and Publication Date:
April 2012Published
January 2012Made publicly available
Date Deposited: 30 Jan 2012 14:22
Last Modified: 31 Mar 2016 13:49
URI: http://eprints.soton.ac.uk/id/eprint/209395

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