Long term respiratory consequences of intrauterine growth restriction
Pike, Katharine, Pillow, J. Jane and Lucas, Jane S. (2012) Long term respiratory consequences of intrauterine growth restriction. Seminars in Fetal & Neonatal Medicine, 17, (2), 92-98. (doi:10.1016/j.siny.2012.01.003). (PMID:22277109).
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Epidemiological studies demonstrate that in-utero growth restriction and low birth weight are associated with impaired lung function and increased respiratory morbidity from infancy, throughout childhood and into adulthood. Chronic restriction of nutrients and/or oxygen during late pregnancy causes abnormalities in the airways and lungs of offspring, including smaller numbers of enlarged alveoli with thicker septal walls and basement membranes. The structural abnormalities and impaired lung function seen soon after birth persist or even progress with age. These changes are likely to cause lung symptomology through life and hasten lung aging.
|Digital Object Identifier (DOI):||doi:10.1016/j.siny.2012.01.003|
|Keywords:||adult, fetal, intrauterine growth restriction, lung, lung function, lung maturation|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology
R Medicine > RG Gynecology and obstetrics
|Divisions:||Faculty of Medicine > Clinical and Experimental Sciences
|Date Deposited:||30 Jan 2012 14:22|
|Last Modified:||27 Mar 2014 19:50|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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