ELM--the database of eukaryotic linear motifs.


Dinkel, Holger, Michael, Sushama, Weatheritt, Robert J, Davey, Norman E, Van Roey, Kim, Altenberg, Brigitte, Toedt, Grischa, Uyar, Bora, Seiler, Markus, Budd, Aidan, Jödicke, Lisa, Dammert, Marcel A, Schroeter, Christian, Hammer, Maria, Schmidt, Tobias, Jehl, Peter, McGuigan, Caroline, Dymecka, Magdalena, Chica, Claudia, Luck, Katja, Via, Allegra, Chatr-Aryamontri, Andrew, Haslam, Niall, Grebnev, Gleb, Edwards, Richard J, Steinmetz, Michel O, Meiselbach, Heike, Diella, Francesca and Gibson, Toby J (2011) ELM--the database of eukaryotic linear motifs. Nucleic Acids Research, 40, (D1), D242-D251. (doi:10.1093/nar/gkr1064). (PMID:22110040).

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Description/Abstract

Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.eu.org provides the biological community with a comprehensive database of known experimentally validated motifs, and an exploratory tool to discover putative linear motifs in user-submitted protein sequences. The current update of the ELM database comprises 1800 annotated motif instances representing 170 distinct functional classes, including approximately 500 novel instances and 24 novel classes. Several older motif class entries have been also revisited, improving annotation and adding novel instances. Furthermore, addition of full-text search capabilities, an enhanced interface and simplified batch download has improved the overall accessibility of the ELM data. The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances

Item Type: Article
ISSNs: 0305-1048 (print)
1362-4962 (electronic)
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Natural and Environmental Sciences > Biological Sciences
Faculty of Natural and Environmental Sciences > Biological Sciences > Molecular & Cellular
ePrint ID: 210853
Date Deposited: 16 Feb 2012 11:48
Last Modified: 27 Mar 2014 19:50
Research Funder: BBSRC
Projects:
Integrated in silico prediction of protein interaction motifs using interactome networks and high-resolution 3-dimensional structures
Funded by: BBSRC (BB/I006230/1)
Led by: Richard John Edwards
29 June 2011 to 30 September 2014
URI: http://eprints.soton.ac.uk/id/eprint/210853

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