Tunable transmembrane chloride transport by bis-indolylureas

Haynes, Cally J.E., Moore, Stephen J., Hiscock, Jennifer R., Marques, Igor, Costa, Paulo Jorge, Félix, Vítor and Gale, Philip A. (2012) Tunable transmembrane chloride transport by bis-indolylureas. Chemical Science, 3, 1436-1444. (doi:10.1039/C2SC20041D).


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A series of bis-indolylureas have been found to mediate chloride transport across vesicle bilayers. The anion transport activity of these receptors may be readily modulated by small structural changes to the receptor scaffold as shown by the combination of experimental chloride efflux studies and molecular dynamics simulations in water and POPC bilayer

Item Type: Article
Digital Object Identifier (DOI): doi:10.1039/C2SC20041D
ISSNs: 2041-6520 (print)
2041-6539 (electronic)
Subjects: Q Science > QD Chemistry
Divisions : ?? uos2011-F6-EB-ES ??
ePrint ID: 210962
Accepted Date and Publication Date:
9 February 2012Made publicly available
Date Deposited: 16 Feb 2012 15:26
Last Modified: 31 Mar 2016 13:49
Selective Receptors for the Transmembrane Transport of Bicarbonate Anion
Funded by: EPSRC (EP/G002576/1)
Led by: Philip Alan Gale
1 October 2008 to 31 March 2012
URI: http://eprints.soton.ac.uk/id/eprint/210962

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