A Large-Scale Simulation of the Piriform Cortex by a Cell Automaton-Based Network Model

Claverol, E.T., Brown, A.D. and Chad, J.E. (2002) A Large-Scale Simulation of the Piriform Cortex by a Cell Automaton-Based Network Model. IEEE Transactions on Biomedical Engineering, 49, (9), 921-935. (doi:10.1109/TBME.2002.801986).


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An event-driven framework is used to construct a
physiologically motivated large-scale model of the piriform cortex
containing in the order of 105 neuron-like computing units. This
approach is based on a hierarchically defined highly abstract
neuron model consisting of finite-state machines. It provides computational
efficiency while incorporating components which have
identifiable counterparts in the neurophysiological domain. The
network model incorporates four neuron types, and glutamatergic
excitatory and and inhibitory synapses.
The spatio-temporal patterns of cortical activity and the temporal
and spectral characteristics of simulated electroencephalograms
(EEGs) are studied. In line with previous experimental and
compartmental work, 1) shock stimuli elicit EEG profiles with either
isolated peaks or damped oscillations, the response type being
determined by the intensity of the stimuli, and 2) temporally unpatterned
input generates EEG oscillations supported by model-wide
waves of excitation.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1109/TBME.2002.801986
ISSNs: 0018-9294 (print)
Related URLs:
Keywords: Cell automata, discrete simulation, EEG oscillations, piriform olfactory cortex, pulse-coded neuron model.
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: University Structure - Pre August 2011 > School of Electronics and Computer Science
University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 24088
Date :
Date Event
Date Deposited: 22 Mar 2006
Last Modified: 31 Mar 2016 11:45
URI: http://eprints.soton.ac.uk/id/eprint/24088

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