Nitric oxide modulates presynaptic afferent depolarization of mechanosensory neurons

Schuppe, Hansjürgen and Newland, Philip L. (2004) Nitric oxide modulates presynaptic afferent depolarization of mechanosensory neurons. Journal of Neurobiology, 59, (3), 331-342. (doi:10.1002/neu.10333).


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In crayfish, movement of the tailfan causes stimulation of exteroceptive sensory hairs located
on its surface. Movement is monitored by a proprioceptor,
the protopodite-endopodite chordotonal organ
within the tailfan. Proprioceptive afferents provide indirect
presynaptic inhibitory inputs to sensory hair afferents
in the form of primary afferent depolarizations
(PADs). Bath application of nitric oxide (NO) substrates,
donors and scavengers, and nitric oxide synthase (NOS)
inhibitors had no effect on the responses of proprioceptive
afferents during imposed movements of the chordotonal
organ. In contrast, the amplitude of PADs in
exteroceptive hair afferents was dependent on NO levels.
NO levels were altered by bath-application of the NOprecursor
L-arginine, the NO donor SNAP, the NOSinhibitor
L-NAME, and the NO scavenger PTIO, while
changes in PAD amplitude were measured. Application
of L-arginine or SNAP resulted in consistent decreases in
PAD amplitude, whereas L-NAME and PTIO induced
increases in PAD amplitude. These results suggest that
endogenous NO decreases inhibitory inputs to exteroceptive
neurons, thus enhancing transmitter release at
their output synapses.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/neu.10333
ISSNs: 0022-3034 (print)
Related URLs:
Keywords: neuromodulation, presynaptic inhibition, local circuit, reflex, crayfish
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QH Natural history > QH301 Biology
Divisions : University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 24212
Accepted Date and Publication Date:
June 2004Published
Date Deposited: 28 Mar 2006
Last Modified: 31 Mar 2016 11:45

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