Bromelain as a treatment for osteoarthritis: a review of clinical studies


Brien, Sarah, Lewith, George, Walker, Ann, Hicks, Stephen M. and Middleton, Dick (2004) Bromelain as a treatment for osteoarthritis: a review of clinical studies. Evidence-based Complementary and Alternative Medicine, 1, (3), 251-257. (doi:10.1093/ecam/neh035).

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Original Publication URL: http://dx.doi.org/10.1093/ecam/neh035

Description/Abstract

Bromelain, an extract from the pineapple plant, has been demonstrated to show anti-inflammatory and analgesic properties and may provide a safer alternative or adjunctive treatment for osteoarthritis. All previous trials, which have been uncontrolled or comparative studies, indicate its potential use for the treatment of osteoarthritis. This paper reviews the mechanism of its putative therapeutic actions, those clinical trials that have assessed its use in osteoarthritis to date, as well as considering the safety implications of this supplement for osteoarthritis and reviewing the evidence to date regarding the dosage for treating this condition. The data available at present indicate the need for trials to establish the efficacy and optimum dosage for bromelain and the need for adequate prospective adverse event monitoring in such chronic conditions as osteoarthritis.

Item Type: Article
Related URLs:
Keywords: bromelain, herbal, osteoarthritis, proteolytic enzymes, review
Subjects: R Medicine > RZ Other systems of medicine
R Medicine > RS Pharmacy and materia medica
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 24282
Date Deposited: 31 Mar 2006
Last Modified: 27 Mar 2014 18:13
URI: http://eprints.soton.ac.uk/id/eprint/24282

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