Managing nocturnal leg cramps — calf-stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial
Coppin, Richard J., Wicke, Dorothy M. and Little, Paul S. (2005) Managing nocturnal leg cramps — calf-stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial. British Journal of General Practice, 55, (512), 186-191.
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Background: quinine is a common treatment for nocturnal leg cramps but has potential side effects. An uncontrolled study suggested that calf-stretching exercises could prevent nocturnal leg cramps (night cramps) but these findings have never been confirmed.
Aim: to assess the effect of calf-stretching exercises and cessation of quinine treatment for patients with night cramps taking quinine.
Design of study: randomised controlled trial.
Setting: twenty-eight general practices in southern England.
Method: one hundred and ninety-one patients prescribed quinine for night cramps were randomised to one of four groups defined by two 'advice' factors: undertake exercises and stop quinine. After 6 weeks they were advised that they could take quinine and undertake the exercises freely. Documentation of cramp at 12 weeks was achieved in 181 (95%) patients. Main outcome measures were: symptom burden score, and frequency of night cramps and quinine usage.
Results: at 12 weeks there was no significant difference in number of cramps in the previous 4 weeks (exercise = 1.95, 95% confidence interval [CI] = -3.01 to 6.90; quinine cessation = 3.45, 95% CI = -1.52 to 8.41) nor symptom burden or severity of cramps. However, after 12 weeks 26.5% (95% CI = 13.3% to 39.7%) more patients who had been advised to stop quinine treatment reported taking no quinine tablets in the previous week (odds ratio [OR] = 3.32, 95% CI = 1.37 to 8.06), whereas advice to do stretching exercises had no effect (OR = 0.73, 95% CI = 0.27 to 1.98).
Conclusions: calf-stretching exercises are not effective in reducing the frequency or severity of night cramps. Advising those on long-term repeat prescriptions to try stopping quinine temporarily will result in no major problems for patients, and allow a significant number to stop medication.
|Keywords:||exercise therapy, muscle cramp, nocturnal leg cramps, primary health care, quinine, ransomised controlled, trials|
|Subjects:||R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine|
|Divisions :||University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
|Accepted Date and Publication Date:||
|Date Deposited:||29 Mar 2006|
|Last Modified:||31 Mar 2016 11:45|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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