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Ntab, a novel non-coding RNA abundantly expressed in rat brain

Ntab, a novel non-coding RNA abundantly expressed in rat brain
Ntab, a novel non-coding RNA abundantly expressed in rat brain
We have identified a novel transcript that is abundantly and specifically expressed in both the adult and developing rat CNS. Within the full-length cDNA sequence we were unable to identify a clear open reading frame. Moreover, we were unable to detect any protein product derived from the full-length cDNA sequence using an in vitro translation assay. Therefore, we suggest this gene is one of a growing number of non-coding mRNA-like RNA transcripts that exert their cellular functions directly as an RNA. We have named this novel gene Ntab for non-coding transcript abundantly expressed in brain (accession number AY035551). In addition, in some regions of the brain we find evidence for RNA accumulation in cellular processes at some distance from the soma. These findings suggest that Ntab is actively transported and may function within cellular processes. Since Ntab is a targeted non-coding RNA, such cellular functions could include the targeting and/or regulation of localised translation of other mRNA species.
neural gene expression, non-coding RNA, RNA targeting, cerebellum.
0306-4522
207-215
French, P.J.
10c75469-53aa-449c-b8d6-9ef444b697b7
Bliss, T.V.P.
a448eacf-9563-4c65-93b0-a967ac4f3d30
O'Connor, V.
8021b06c-01a0-4925-9dde-a61c8fe278ca
French, P.J.
10c75469-53aa-449c-b8d6-9ef444b697b7
Bliss, T.V.P.
a448eacf-9563-4c65-93b0-a967ac4f3d30
O'Connor, V.
8021b06c-01a0-4925-9dde-a61c8fe278ca

French, P.J., Bliss, T.V.P. and O'Connor, V. (2001) Ntab, a novel non-coding RNA abundantly expressed in rat brain. Neuroscience, 108 (2), 207-215. (doi:10.1016/S0306-4522(01)00408-0).

Record type: Article

Abstract

We have identified a novel transcript that is abundantly and specifically expressed in both the adult and developing rat CNS. Within the full-length cDNA sequence we were unable to identify a clear open reading frame. Moreover, we were unable to detect any protein product derived from the full-length cDNA sequence using an in vitro translation assay. Therefore, we suggest this gene is one of a growing number of non-coding mRNA-like RNA transcripts that exert their cellular functions directly as an RNA. We have named this novel gene Ntab for non-coding transcript abundantly expressed in brain (accession number AY035551). In addition, in some regions of the brain we find evidence for RNA accumulation in cellular processes at some distance from the soma. These findings suggest that Ntab is actively transported and may function within cellular processes. Since Ntab is a targeted non-coding RNA, such cellular functions could include the targeting and/or regulation of localised translation of other mRNA species.

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More information

Published date: 2001
Keywords: neural gene expression, non-coding RNA, RNA targeting, cerebellum.

Identifiers

Local EPrints ID: 24588
URI: http://eprints.soton.ac.uk/id/eprint/24588
ISSN: 0306-4522
PURE UUID: f4c2c54d-0e06-4322-abec-8b9e91d12b89
ORCID for V. O'Connor: ORCID iD orcid.org/0000-0003-3185-5709

Catalogue record

Date deposited: 31 Mar 2006
Last modified: 16 Mar 2024 03:13

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Contributors

Author: P.J. French
Author: T.V.P. Bliss
Author: V. O'Connor ORCID iD

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