A perspective on inversin
Eley, Lorraine, Turnpenny, Lee, Yates, Laura M., Craighead, A. Scott, Morgan, David, Whistler, Catherine, Goodship, Judith A. and Strachan, Tom (2004) A perspective on inversin. Cell Biology International, 28, (2), 119-124. (doi:10.1016/j.cellbi.2003.11.009).
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Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left–right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left–right axis and renal function remains to be elucidated.
|Additional Information:||Primary Cilia|
|Keywords:||inversin, situs inversus, primary cilia, nephronopthisis|
|Subjects:||R Medicine > RB Pathology
Q Science > QP Physiology
Q Science > QH Natural history > QH301 Biology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Human Genetics
|Date Deposited:||03 Apr 2006|
|Last Modified:||27 Mar 2014 18:13|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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