Microarray analysis of peroxisome proliferator-activated receptor-γ induced changes in gene expression in macrophages
Hodgkinson, Conrad P. and Ye, Shu (2003) Microarray analysis of peroxisome proliferator-activated receptor-γ induced changes in gene expression in macrophages. Biochemical and Biophysical Research Communications, 308, (3), 505-510. (doi:10.1016/S0006-291X(03)01416-5).
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Description/Abstract
We used a combination of expression microarray and Northern blot analyses to identify target genes for peroxisome proliferator-activated receptor (PPAR) γ in RAW264.7 macrophages. PPARγ natural ligand 15-deoxy-Δ12,14 prostaglandin and synthetic ligands ciglitazone and rosiglitazone increased the expression of scavenger receptor CD36 and ATP-binding cassette transporter A1, as well as adipophilin (a lipid droplet coating protein involved in intracellular lipid storage and transport), calpain (a protease implicated in ABCA1 protein degradation), and ADAM8 (a disintegrin and metalloprotease protein involved in cell adhesion). These findings are relevant to understanding the effect of PPARγ activation on gene expression and cognate pathways in macrophages.
| Item Type: | Article |
|---|---|
| ISSNs: | 0006-291X (print) |
| Related URLs: | |
| Keywords: | peroxisome proliferator,activated receptor-γ, macrophages, gene expression, microarray analysis |
| Subjects: | R Medicine > R Medicine (General) Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| Item ID: | 24753 |
| Date Deposited: | 05 Apr 2006 |
| Last Modified: | 02 Mar 2012 12:04 |
| Contributors: | Hodgkinson, Conrad P. (Author) Ye, Shu (Author) |
| Date: | 2003 |
| Status: | Published |
| Contact Email Address: | cph@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/24753 |
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