An 11p;17p telomeric translocation in two families associated with recurrent miscarriages and Miller-Dieker syndrome
Joyce, Christine A., Dennis, Nicholas R., Howard, Francis, Davis, Louisa M. and Thomas, N. Simon (2002) An 11p;17p telomeric translocation in two families associated with recurrent miscarriages and Miller-Dieker syndrome. European Journal of Human Genetics, 10, (11), 707-714. (doi:10.1038/sj.ejhg.5200882).
Translocations occur in a proportion of couples affected by recurrent miscarriages. We describe two such families in which the underlying cause was a cryptic subtelomeric 11p;17p translocation detected only after the birth of an affected child carrying an unbalanced form of the rearrangement. Unbalanced subtelomeric rearrangements are now recognised as a significant cause of mental impairment and we believe that these rearrangements may also be an important cause of recurrent miscarriages. In these two families the translocation is most likely to have arisen from a single ancestral event because all translocation carriers shared almost identical haplotypes around the breakpoints on both chromosomes.
|Keywords:||recurrent miscarriages, miller-dieker syndrome, subtelomere fish, cryptic rearrangements|
|Subjects:||H Social Sciences > HQ The family. Marriage. Woman
R Medicine > R Medicine (General)
Q Science > QH Natural history > QH426 Genetics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Human Genetics
|Date Deposited:||05 Apr 2006|
|Last Modified:||28 Jun 2012 10:05|
|Contact Email Address:||email@example.com|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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