LDB2000: sequence-based integrated maps of the human genome
LDB2000: sequence-based integrated maps of the human genome
MOTIVATION:
Integrated maps are useful for gene mapping and establishing the relationship between recombination and sequence. In this paper we describe algorithms and their implementation for constructing sequence-based integrated maps of the human chromosomes, which are presented in LDB2000, a web based resource. Gene mapping efforts are now focussing on linkage disequilibrium mapping and extension of the integrated map to represent the extent of linkage disequilibrium in different genomic regions would further increase the utility of these maps.
RESULTS:
Sequence-based integrated maps have been completed for chromosomes 21 and 22. These maps provide locations for genes and polymorphic markers in sequence and on genetic linkage, radiation hybrid and cytogenetic scales. Single nucleotide polymorphisms associated with genes in the maps are also included and their sequence locations indicated. Related locus information, such as aliases and expression information, can be searched on the WWW site.
Algorithms, Chromosome Mapping, Chromosomes, Human, Pair 21/genetics, Chromosomes, Human, Pair 22/genetics, Computational Biology, Genome, Human, Humans, Internet, Linkage Disequilibrium, Software
581-586
Ke, X
7ce19883-4155-4457-b239-efe78e8087ff
Tapper, W
9d5ddc92-a8dd-4c78-ac67-c5867b62724c
Collins, A
2b0f10ef-06eb-4956-8fca-e6d254e9dce9
July 2001
Ke, X
7ce19883-4155-4457-b239-efe78e8087ff
Tapper, W
9d5ddc92-a8dd-4c78-ac67-c5867b62724c
Collins, A
2b0f10ef-06eb-4956-8fca-e6d254e9dce9
Abstract
MOTIVATION:
Integrated maps are useful for gene mapping and establishing the relationship between recombination and sequence. In this paper we describe algorithms and their implementation for constructing sequence-based integrated maps of the human chromosomes, which are presented in LDB2000, a web based resource. Gene mapping efforts are now focussing on linkage disequilibrium mapping and extension of the integrated map to represent the extent of linkage disequilibrium in different genomic regions would further increase the utility of these maps.
RESULTS:
Sequence-based integrated maps have been completed for chromosomes 21 and 22. These maps provide locations for genes and polymorphic markers in sequence and on genetic linkage, radiation hybrid and cytogenetic scales. Single nucleotide polymorphisms associated with genes in the maps are also included and their sequence locations indicated. Related locus information, such as aliases and expression information, can be searched on the WWW site.
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More information
Published date: July 2001
Keywords:
Algorithms, Chromosome Mapping, Chromosomes, Human, Pair 21/genetics, Chromosomes, Human, Pair 22/genetics, Computational Biology, Genome, Human, Humans, Internet, Linkage Disequilibrium, Software
Identifiers
Local EPrints ID: 24799
URI: http://eprints.soton.ac.uk/id/eprint/24799
ISSN: 1367-4803
PURE UUID: cc97adc4-6b7e-485d-8367-92ee02e6ee72
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Date deposited: 05 Apr 2006
Last modified: 16 Mar 2024 03:07
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Contributors
Author:
X Ke
Author:
A Collins
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