Response of hepatic proteins to the lowering of habitual dietary protein to the recommended safe level of intake

Afolabi, Paul R., Jahoor, Farook, Gibson, Neil R. and Jackson, Alan A. (2004) Response of hepatic proteins to the lowering of habitual dietary protein to the recommended safe level of intake. American Journal of Physiology. Endocrinology and Metabolism, 287, (2), E327-E330. (doi:10.1152/ajpendo.00036.2004).


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The plasma concentrations of albumin, HDL apolipoprotein A1 (apoA1), retinol-binding protein (RBP), transthyretin (TTR), haptoglobulin, and fibrinogen were measured, and a stable isotope infusion protocol was used to determine the fractional and absolute synthesis rates of RBP, TTR, and fibrinogen in 12 young adults on three occasions during a reduction of their habitual protein intake from 1.13 to 0.75 g·kg–1·day–1 for 10 days. This study was performed to determine whether healthy adults could maintain the rates of synthesis of selected nutrient transport and positive acute-phase proteins when consuming a protein intake of 0.75 g·kg–1·day–1. During the lower protein intake, the plasma concentration of all the proteins, other than HDL-apoA1, remained unchanged. HDL-apoA1 concentration was significantly reduced (P < 0.05) after 3 days of the lower protein intake, but not at 10 days. The rates of synthesis of RBP and TTR declined significantly (P < 0.05), whereas the rate of synthesis of fibrinogen remained unchanged. The results indicate that, when normal adults consume the recommended safe level of protein, 0.75 g·kg–1·day–1, there is a slower rate of turnover of nutrient transport proteins than on their habitual diet. Hence, healthy individuals consuming this amount of protein may be less able to mount an adequate metabolic response to a stressful stimulus.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1152/ajpendo.00036.2004
ISSNs: 0193-1849 (print)
Related URLs:
Keywords: protein requirements, acute-phase proteins, nutrient transport proteins
Subjects: R Medicine > R Medicine (General)
Q Science > QP Physiology
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25180
Accepted Date and Publication Date:
Date Deposited: 06 Apr 2006
Last Modified: 31 Mar 2016 11:47

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