The malnourished baby and infant: relationship with type 2 diabetes

Barker, David J.P. (2001) The malnourished baby and infant: relationship with type 2 diabetes. British Medical Bulletin, 60, (1), 69-88. (doi:10.1093/bmb/60.1.69).


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The growth of a baby is constrained by the nutrients and oxygen it receives from the mother. A mother's ability to nourish her baby is established during her own fetal life and by her nutritional experiences in childhood and adolescence, which determine her body size, composition and metabolism. Mother's diet in pregnancy has little effect on the baby's size at birth, but nevertheless programmes the baby. The fetus adapts to undernutrition by changing its metabolism, altering its production of hormones and the sensitivity of tissues to them, redistributing its blood flow, and slowing its growth rate. In some circumstances, the placenta may enlarge. Adaptations to undernutrition that occur during development permanently alter the structure and function of the body.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1093/bmb/60.1.69
Related URLs:
Subjects: R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25224
Accepted Date and Publication Date:
Date Deposited: 07 Apr 2006
Last Modified: 31 Mar 2016 11:47

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