Coronary heart disease: a disorder of growth

Barker, D. J. P. (2003) Coronary heart disease: a disorder of growth. Hormone Research, 59, (Supp.1), 35-41. (doi:10.1159/000067843).


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A new 'developmental' model for the origins of coronary heart disease and the related disorders of type 2 diabetes, hypertension and stroke is emerging. The finding that people who develop these disorders have altered growth in utero, during infancy and childhood provides a new starting point for research. The immediate prospect for prevention is through protecting infant growth and preventing accelerated weight gain in children made vulnerable to later disease by small size at birth and during infancy. Ultimately we need to optimize maternal diet and composition before and during pregnancy. Despite current levels of nutrition in Western countries the nutrition of many fetuses and infants remains suboptimal because the nutrients available are unbalanced or because their delivery is constrained by the long and vulnerable fetal supply line.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1159/000067843
Additional Information: Supplement is also available as: ISBN 3-8055-7539-4 Proceedings of the 13th Novo Nordisk Symposium on Growth Hormone and Endocrinology Budapest, April 12-13, 2002 and Proceedings of the SGA/IUGR Satellite Symposium Budapest, April 11, 2002 Editors: M.B. Ranke, Tübingen; J.S. Christiansen, Aarhus
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Keywords: coronary heart disease, fetal and childhood growth, developmental plasticity
Subjects: R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25230
Accepted Date and Publication Date:
Date Deposited: 07 Apr 2006
Last Modified: 31 Mar 2016 11:47

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