The developmental origins of chronic adult disease

Barker, D.J.P. (2004) The developmental origins of chronic adult disease. Acta Paediatrica.Supplement, 93, (446), 26-33. (doi:10.1080/08035320410022730).


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Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1080/08035320410022730
ISSNs: 0803-5326 (print)
Related URLs:
Subjects: R Medicine > RB Pathology
Q Science > QP Physiology
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25237
Accepted Date and Publication Date:
Date Deposited: 12 Apr 2006
Last Modified: 31 Mar 2016 11:47

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