Developmental plasticity and human health
Bateson, Patrick, Barker, David, Clutton-Brock, Timothy, Deb, Debal, D'Udine, Bruno, Foley, Robert A., Gluckman, Peter D., Godfrey, Keith M., Kirkwood, Tom, Mirazón-Lahr, Marta Mirazón, McNamara, John, Metcalfe, Neil B., Monaghan, Patricia, Spencer, Hamish G. and Sultan, Sonia E. (2004) Developmental plasticity and human health. Nature, 430, (6998), 419-421. (doi:10.1038/nature02725).
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Many plants and animals are capable of developing in a variety of ways, forming characteristics that are well adapted to the environments in which they are likely to live. In adverse circumstances, for example, small size and slow metabolism can facilitate survival, whereas larger size and more rapid metabolism have advantages for reproductive success when resources are more abundant. Often these characteristics are induced in early life or are even set by cues to which their parents or grandparents were exposed. Individuals developmentally adapted to one environment may, however, be at risk when exposed to another when they are older. The biological evidence may be relevant to the understanding of human development and susceptibility to disease. As the nutritional state of many human mothers has improved around the world, the characteristics of their offspring—such as body size and metabolism—have also changed. Responsiveness to their mothers' condition before birth may generally prepare individuals so that they are best suited to the environment forecast by cues available in early life. Paradoxically, however, rapid improvements in nutrition and other environmental conditions may have damaging effects on the health of those people whose parents and grandparents lived in impoverished conditions. A fuller understanding of patterns of human plasticity in response to early nutrition and other environmental factors will have implications for the administration of public health.
|Subjects:||R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Q Science > QP Physiology
Q Science > QH Natural history > QH301 Biology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||10 Apr 2006|
|Last Modified:||01 Apr 2012 02:12|
|Contact Email Address:||firstname.lastname@example.org|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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