Mechanisms underlying the programming of small artery dysfunction: review of the model using low protein diet in pregnancy in the rat
Brawley, L., Poston, L. and Hanson, M. A. (2003) Mechanisms underlying the programming of small artery dysfunction: review of the model using low protein diet in pregnancy in the rat. Archives of Physiology and Biochemistry, 111, (1), 23-35. (doi:10.1076/apab.22.214.171.12438).
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Human and animal studies have shown that unbalanced maternal nutrition is associated with the development of cardiovascular and metabolic disease in adulthood. In the Southampton maternal low protein model (SMLP), protein deprivation (50%) throughout pregnancy in rats leads to elevated blood pressure in adult offspring. Impaired peripheral arterial function may contribute to the cardiovascular dysfunction observed in these offspring. This review discusses the impact of such a dietary insult on the vascular function of resistance arteries from pregnant rats (pF 0 ), their offspring (F 1 ), the pregnant offspring (pF 1 ) and the second generation (F 2 ). At each stage, disturbances in endothelium-dependent relaxation were observed, implicating changes in endothelial nitric oxide (NO)-guanylate cyclase (GC) signalling pathway in the vascular adaptations to pregnancy and the programmed effects on offspring.
|Digital Object Identifier (DOI):||doi:10.1076/apab.126.96.36.19938|
|Keywords:||vascular, low protein, nitric oxide, programming, pregnancy, vascular endothelial growth factor, mesenteric, uterine, thoracic aorta, transgenerational.|
|Subjects:||R Medicine > RG Gynecology and obstetrics
Q Science > QP Physiology
Q Science > QH Natural history > QH301 Biology
|Divisions :||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Accepted Date and Publication Date:||
|Date Deposited:||07 Apr 2006|
|Last Modified:||31 Mar 2016 11:47|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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