Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women
Burdge, G.C. and Wootton, S.A. (2003) Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. Prostaglandins, Leukotrienes and Essential Fatty Acids, 69, (4), 283-290. (doi:10.1016/S0952-3278(03)00111-X).
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Description/Abstract
The purpose of this study was to determine whether adult humans can recycle carbon from α-linolenic acid (18:3n-3) into saturated (SFA) and monounsaturated (MUFA) fatty acids. Six men and six women consumed 700 mg [U-13C]-18:3n-3. Blood was collected over 21 days and breath over 24 h. [13C]-labelled SFA and MUFA were detected in plasma phosphatidylcholine (PC) and triacylglycerol (TAG). Total labelled fatty acid incorporation into SFA and MUFA was five- and 25-fold greater in PC than TAG in men and women, respectively. [13C]-16:0 was the major labelled fatty acid in both fractions. Total [13C] incorporation into SFA and MUFA was 20% greater in men than women, and related positively (r2=0.35,P<0.05) to the fractional recovery of labelled 18:3n-3 as 13CO2 on breath. These results suggest that the extent of partitioning towards β-oxidation and carbon recycling may regulate the availability of 18:3n-3 for conversion to longer-chain fatty acids.
| Item Type: | Article |
|---|---|
| ISSNs: | 0952-3278 (print) |
| Related URLs: | |
| Keywords: | α-linolenic acid, gender, saturated fatty acid, monounsaturated fatty acid, stable isotope, human |
| Subjects: | R Medicine > R Medicine (General) Q Science > QP Physiology Q Science > QR Microbiology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease |
| Item ID: | 25288 |
| Date Deposited: | 10 Apr 2006 |
| Last Modified: | 02 Mar 2012 13:27 |
| Contributors: | Burdge, G.C. (Author) Wootton, S.A. (Author) |
| Date: | 2003 |
| Status: | Published |
| Contact Email Address: | g.c.burdge@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/25288 |
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