The University of Southampton
University of Southampton Institutional Repository

Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men

Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men
Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men
Objective: To investigate whether the postprandial changes in plasma triacylglycerol (TAG), nonesterified fatty acids (NEFA), glucose and insulin concentrations in young men were the same if an identical meal was fed at breakfast and lunch, and if the response to lunch was modified by consumption of breakfast.

Methods: In two trials (1 and 2) healthy subjects (age 22±1 y, body mass index 22±2 kg/m2) were fed the same mixed macronutrient meal at breakfast at 08:00 h and lunch at 14:00 h. In the third trial, no breakfast was fed and the overnight fast extended until lunch at 14:00 h. Addition of [1,1,1-13C]tripalmitin to one meal in each trial was used to distinguish between endogenous and meal-derived lipids.

Results: The postprandial changes in TAG, NEFA and glucose concentrations were similar in trials 1 and 2. The change in plasma total TAG concentration was about two fold less (P<0.05) after lunch compared to breakfast. Postprandial NEFA suppression was the same after breakfast and lunch. Glucose and insulin responses were significantly greater following lunch suggesting decreasing insulin sensitivity during the day. Consumption of breakfast did not alter the postprandial total TAG or NEFA responses after lunch. Measurement of [13C]palmitic acid concentration showed that handling of TAG and NEFA from the meal was the same after breakfast and lunch, and was not altered by consumption of breakfast.

Conclusions: Overall, these data suggest that in young, healthy men regulation of plasma TAG from endogenous sources, principally VLDL, but not chylomicrons during the postprandial period leads to differences in the magnitude of lipaemic response when the same meal was consumed at breakfast or at lunch 6 h later.

stable isotope, postprandial lipaemia, men
0954-3007
1536-1544
Burdge, G.C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Jones, A.E.
61f65ad1-ae5c-47f6-b159-63aa6a5178b5
Frye, S.M.
49f4ab52-d3bc-4980-888e-d8552a33191b
Goodson, L.
3112cb46-58d8-4dc5-b111-415880a03c7d
Wootton, S.A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Burdge, G.C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Jones, A.E.
61f65ad1-ae5c-47f6-b159-63aa6a5178b5
Frye, S.M.
49f4ab52-d3bc-4980-888e-d8552a33191b
Goodson, L.
3112cb46-58d8-4dc5-b111-415880a03c7d
Wootton, S.A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c

Burdge, G.C., Jones, A.E., Frye, S.M., Goodson, L. and Wootton, S.A. (2003) Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men. European Journal of Clinical Nutrition, 57 (12), 1536-1544. (doi:10.1038/sj.ejcn.1601722).

Record type: Article

Abstract

Objective: To investigate whether the postprandial changes in plasma triacylglycerol (TAG), nonesterified fatty acids (NEFA), glucose and insulin concentrations in young men were the same if an identical meal was fed at breakfast and lunch, and if the response to lunch was modified by consumption of breakfast.

Methods: In two trials (1 and 2) healthy subjects (age 22±1 y, body mass index 22±2 kg/m2) were fed the same mixed macronutrient meal at breakfast at 08:00 h and lunch at 14:00 h. In the third trial, no breakfast was fed and the overnight fast extended until lunch at 14:00 h. Addition of [1,1,1-13C]tripalmitin to one meal in each trial was used to distinguish between endogenous and meal-derived lipids.

Results: The postprandial changes in TAG, NEFA and glucose concentrations were similar in trials 1 and 2. The change in plasma total TAG concentration was about two fold less (P<0.05) after lunch compared to breakfast. Postprandial NEFA suppression was the same after breakfast and lunch. Glucose and insulin responses were significantly greater following lunch suggesting decreasing insulin sensitivity during the day. Consumption of breakfast did not alter the postprandial total TAG or NEFA responses after lunch. Measurement of [13C]palmitic acid concentration showed that handling of TAG and NEFA from the meal was the same after breakfast and lunch, and was not altered by consumption of breakfast.

Conclusions: Overall, these data suggest that in young, healthy men regulation of plasma TAG from endogenous sources, principally VLDL, but not chylomicrons during the postprandial period leads to differences in the magnitude of lipaemic response when the same meal was consumed at breakfast or at lunch 6 h later.

This record has no associated files available for download.

More information

Published date: 2003
Additional Information: Original Communication
Keywords: stable isotope, postprandial lipaemia, men

Identifiers

Local EPrints ID: 25290
URI: http://eprints.soton.ac.uk/id/eprint/25290
ISSN: 0954-3007
PURE UUID: 7a5d77ba-5fd3-4b89-8321-f4f19e9226ca
ORCID for G.C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 15 Mar 2024 07:01

Export record

Altmetrics

Contributors

Author: G.C. Burdge ORCID iD
Author: A.E. Jones
Author: S.M. Frye
Author: L. Goodson
Author: S.A. Wootton

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×