Evidence of sexual dimorphism in relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study
Dennison, Elaine, Syddall, Holly, Fall, Caroline and Cooper, Cyrus (2005) Evidence of sexual dimorphism in relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study. Journal of Rheumatology, 32, (12), 2400-2404.
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Objective: to examine the relationship between estrogen receptor (ER) a and ß gene polymorphisms and bone mass.
Methods: bone mineral density (BMD) was measured at the lumbar spine and proximal femur twice, 4 years apart, in a cohort of 147 men and 125 women aged 61-73 years. Genomic DNA was extracted from whole blood samples, and genotyping for the ER (PvuII, XbaI, and AluI) was undertaken.
Results: there were no significant associations between either the XbaI or PvuII polymorphisms and bone mass, or bone loss in the cohort as a whole. However, men homozygous for the aa ß receptor polymorphism had higher BMD at the lumbar spine (p = 0.05), femoral neck (p = 0.01), and total femur (p = 0.01). Women homozygous for aa had lower femoral neck and total femoral BMD than women of the AA or Aa genotypes (p = 0.01 and p = 0.02). Gender*ERß interaction terms were statistically significant (p = 0.02 for lumbar spine BMD, p = 0.0004 for femoral neck BMD, and p = 0.0003 for total femoral BMD, each test with 2 degrees of freedom unadjusted). Adjustment for sex hormone concentration and lifestyle factors made little difference to our results.
Conclusion: we found relationships between the ERß gene and the determination of bone mass among men and women in their seventh decade.
|Keywords:||estrogen receptor, interaction, bone|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||07 Apr 2006|
|Last Modified:||01 Jun 2011 11:16|
|Contributors:||Dennison, Elaine (Author)
Syddall, Holly (Author)
Fall, Caroline (Author)
Cooper, Cyrus (Author)
|Contact Email Address:||email@example.com|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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