Relationship of maternal protein turnover and lean body mass during pregnancy and birth length


Duggleby, Sarah L. and Jackson, Alan A. (2001) Relationship of maternal protein turnover and lean body mass during pregnancy and birth length. Clinical Science, 101, (1), 65-72.

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Description/Abstract

Epidemiological evidence shows that small size at birth is associated with an increased risk of developing cardiovascular and metabolic disease in adult life. We have examined the relationships between size at birth and maternal body composition and protein turnover in normal pregnant women. A group of 27 multiparous Caucasian women with singleton pregnancies were studied at around 18 and 28 weeks' gestation. Body composition was determined by anthropometry, and whole-body protein turnover was estimated by using a single oral dose of [15N]glycine and the end-product method. The baby's weight and length were measured within 48 h of birth. Mothers with a greater lean body mass had higher rates of protein turnover at 18 weeks' gestation. This association was largely accounted for by differences in the mother's visceral, rather than muscle, mass. Mothers who had higher protein turnover at 18 weeks' gestation had babies that were longer at birth. After adjustment for the duration of gestation and the baby's sex, 26% of the variation in length at birth was accounted for by maternal protein synthesis at 18 weeks' gestation. Maternal protein intake was not associated with the baby's birth length. Thus the mother's ability to nourish her fetus is influenced by her body composition and her rate of protein turnover. Dietary intake does not adequately characterize this ability.

Item Type: Article
ISSNs: 0143-5221 (print)
Related URLs:
Keywords: birth length, birth weight, glycine, 15N, pregnancy, protein synthesis, protein turnover
Subjects: R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25418
Date Deposited: 07 Apr 2006
Last Modified: 27 Mar 2014 18:14
Contact Email Address: sld@mrc.soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/25418

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