Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition
Dunstan, J.A., Mori, T.A., Barden, A., Beilin, L.J., Holt, P.G., Calder, P.C., Taylor, A.L. and Prescott, S.L. (2004) Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition. European Journal of Clinical Nutrition, 58, (3), 429-437. (doi:10.1038/sj.ejcn.1601825).
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Objective: the aim of this study was to assess the effects of fish oil supplementation in pregnancy on maternal erythrocyte fatty acid composition at different stages of pregnancy and in the post-partum period, and on neonatal erythrocyte fatty acid composition.
Design: a double-blind, randomised, placebo-controlled study.
Setting: Subiaco, Western Australia.
Subjects: in all, 98 women booked for delivery at St John of God Hospital, Subiaco, were recruited from private rooms of obstetricians. In total, 83 women and their healthy full-term babies completed the study.
Intervention: women received either 4 g of fish oil (n=52) (56% docosahexaenoic acid (DHA) and 28% eicosapentaenoic acid (EPA) or placebo (olive oil) (n=46) per day from 20 weeks gestation until delivery.
Main outcome measures: erythrocyte phospholipid fatty acids were measured in maternal peripheral blood at 20, 30 and 37 weeks of pregnancy and at 6 weeks post partum, and from cord blood collected at birth.
Results: compared to the control group, maternal EPA and DHA were significantly higher in the fish oil group at 30 and 37 weeks gestation, and remained elevated at 6 weeks post partum (P<0.001). The proportions of n-6 polyunsaturated (arachidonic acid, 22:3n-6 and 22:4n-6) were significantly lower in the fish oil supplemented group at the same time periods (P<0.001). Similarly, the proportions of EPA and DHA were significantly higher (P<0.001), and those of n-6 polyunsaturated fatty acids arachidonic acid, 20:3n-6, 22:3n-6 and 22:4n-6 were significantly lower (P<0.001), in erythrocytes from neonates in the fish oil group, compared to those in the control group.
Conclusion: fish oil supplementation from 20 weeks of pregnancy until birth is an effective means of enhancing n-3 fatty acid status of both mothers and neonates. Furthermore, the changes in maternal erythrocyte fatty acid composition are retained until at least 6 weeks post partum. It is essential to assess the effects of concomitant decreases in arachidonic acid status before any dietary recommendations can be made.
|Digital Object Identifier (DOI):||doi:10.1038/sj.ejcn.1601825|
|Keywords:||PUFA, n-3 fatty acids, docosahexaenoic acid, arachidonic acid, fish oil, pregnancy, atopy|
|Subjects:||R Medicine > RG Gynecology and obstetrics|
|Divisions :||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
|Accepted Date and Publication Date:||
|Date Deposited:||07 Apr 2006|
|Last Modified:||31 Mar 2016 11:47|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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