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Immunological therapies for rheumatoid arthritis

Immunological therapies for rheumatoid arthritis
Immunological therapies for rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory arthritis of the synovial joints that causes loss of function and a shortened life expectancy. In the last 10 years there have been major advances in the treatment of RA, including more aggressive use of disease-modifying anti-rheumatic drugs and the development of immune therapies targeted to molecules and cells important in the immunopathogenesis of RA. Molecular messengers that travel between cells (cytokines) have been found to be of major importance. Blocking the cytokine tumour necrosis factor (TNF-) produces significant improvement in RA, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn’s disease. The use of cytokine blockers has shown the extent to which immune and inflammatory pathways are shared in a number of inflammatory diseases. There has also been an important proof of principle that blocking single cytokines can produce profound effects in inflammatory diseases.
0007-1420
71-82
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106

Edwards, C.J. (2005) Immunological therapies for rheumatoid arthritis. British Medical Bulletin, 74, 71-82. (doi:10.1093/bmb/ldh051).

Record type: Article

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory arthritis of the synovial joints that causes loss of function and a shortened life expectancy. In the last 10 years there have been major advances in the treatment of RA, including more aggressive use of disease-modifying anti-rheumatic drugs and the development of immune therapies targeted to molecules and cells important in the immunopathogenesis of RA. Molecular messengers that travel between cells (cytokines) have been found to be of major importance. Blocking the cytokine tumour necrosis factor (TNF-) produces significant improvement in RA, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn’s disease. The use of cytokine blockers has shown the extent to which immune and inflammatory pathways are shared in a number of inflammatory diseases. There has also been an important proof of principle that blocking single cytokines can produce profound effects in inflammatory diseases.

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Published date: 2005

Identifiers

Local EPrints ID: 25439
URI: http://eprints.soton.ac.uk/id/eprint/25439
ISSN: 0007-1420
PURE UUID: fd0bba46-7e76-4aea-8a4a-4f3677487849

Catalogue record

Date deposited: 11 Apr 2006
Last modified: 15 Mar 2024 07:02

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