Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe
Elmes, M., Green, L.R., Poore, K., Newman, J., Burrage, D., Abayasekara, D.R.E., Cheng, Z., Hanson, M.A. and Wathes, D.C. (2005) Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe. Journal of Physiology, 562, (2), 583-592. (doi:10.1113/jphysiol.2004.071969).
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Description/Abstract
Preterm labour is the major cause of perinatal morbidity and mortality in humans. The incidence is around 10% and the causes are often unknown. Consumption of dietary n-6 polyunsaturated fatty acids (PUFAs) in western societies is increasing. These are metabolized to arachidonic acid, the precursor for 2-series prostaglandins (PGs), major signalling molecules during labour. This study investigated the effect of dietary supplementation with linoleic acid (LA, 18: 2, n-6) on parturition. Ewes were fed a control or LA-supplemented diet from 100 days gestation. Labour was induced using a standardized glucocorticoid challenge (dexamethasone, Dex) to the fetus, starting on day 139. Electromyographic (EMG) activity and fetal and maternal circulating PG concentrations were monitored. One third of LA-fed ewes delivered early (pre-Dex) although basal uterine EMG activity preceding Dex was higher in control ewes (P < 0.05). A steep increase in EMG activity occurred 18–38 h after the start of Dex infusion. Twice basal EMG activity (defined as established labour) occurred on average 7 h earlier in the LA-supplemented ewes (P < 0.05). The basal concentrations of maternal and fetal PGFM and fetal PGE2 were approximately doubled in LA-supplemented ewes before the start of Dex infusion (P < 0.01). The rise in fetal PGE2 and maternal oestradiol concentrations post-Dex occurred earlier in the LA-supplemented ewes. All PG measurements remained significantly higher in the LA-supplemented ewes during labour onset. This study suggests that consumption of a high LA diet in late pregnancy can enhance placental PG production and may thus increase the risk of preterm labour.
| Item Type: | Article |
|---|---|
| ISSNs: | 0022-3751 (print) |
| Related URLs: | |
| Subjects: | R Medicine > RG Gynecology and obstetrics Q Science > QP Physiology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease |
| Item ID: | 25461 |
| Date Deposited: | 10 Apr 2006 |
| Last Modified: | 01 Apr 2012 02:16 |
| Contributors: | Elmes, M. (Author) Green, L.R. (Author) Poore, K. (Author) Newman, J. (Author) Burrage, D. (Author) Abayasekara, D.R.E. (Author) Cheng, Z. (Author) Hanson, M.A. (Author) Wathes, D.C. (Author) |
| Date: | 2005 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/25461 |
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