The effects of the Pro12Ala polymorphism of the PPAR?-2 gene on lipid metabolism interact with body size at birth
Eriksson, J., Lindi, V., Uusitupa, M., Forsen, T., Laakso, M., Osmond, C. and Barker, D. (2003) The effects of the Pro12Ala polymorphism of the PPAR?-2 gene on lipid metabolism interact with body size at birth. Clinical Genetics, 64, (4), 366-370. (doi:10.1034/j.1399-0004.2003.00150.x).
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Body size at birth is an indicator of the intrauterine environment. The effects of the Pro12Pro genotype and the 12Ala allele of the PPAR?-2 gene on glucose and insulin metabolism in adult life depend on body size at birth. A low birth weight is associated with insulin resistance and type 2 diabetes. The peroxisome proliferator-activated receptor-? (PPAR?s) are also regulators of adipocyte differentiation, and the PPAR?-2 gene could also contribute to the development of dyslipidemia. Therefore, the effects of the Pro12Ala polymorphisms of the PPAR?-2 gene on lipid metabolism were measured in 476 elderly persons whose birth weight was known. The Ala12 allele was associated with increased serum total, low-density lipoprotein (LDL), and non-high-density lipoprotein (non-HDL) cholesterol concentrations but only among those who had birth weights below 3000 g. These interactions between the effects of the PPAR?-2 gene on adult traits and the effects of birth weight may be interpreted as examples of gene–environmental interactions, which underlie plasticity during development.
|Digital Object Identifier (DOI):||doi:10.1034/j.1399-0004.2003.00150.x|
|Keywords:||birth weight, developmental plasticity, dyslipidemia, gene-enviroment interaction, ppar?-2gene|
|Subjects:||Q Science > QP Physiology
Q Science > QH Natural history > QH426 Genetics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||19 Apr 2006|
|Last Modified:||31 Mar 2016 11:47|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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