Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals


Eriksson, J.G., Forsen, T., Tuomilehto, J., Jaddoe, V.W., Osmond, C. and Barker, D.J.P. (2002) Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals. Diabetologia, 45, (3), 342-348. (doi:10.1007/s00125-001-0757-6).

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Description/Abstract

Aims/hypothesis:
A study of 7086 men and women born in Helsinki, Finland, has shown that the development of Type II (non-insulin-dependent) diabetes mellitus is associated with low birth weight followed by accelerated gain in height and weight during childhood and with high maternal BMI but the processes which underlie these associations are largely not known.

Methods:
We carried out standard oral glucose tolerance tests, and measured plasma insulin and proinsulin, serum lipid concentrations and blood pressure in 474 patients from the Helsinki cohort.

Results:
We used four indices of insulin resistance: fasting and 2-h plasma insulin, and fasting proinsulin and 32-33 split proinsulin concentrations. These were associated with small body size at birth and during childhood, rapid growth in height and low maternal BMI.

Conclusion/interpretation:
Insulin resistance and Type II diabetes share common associations with retarded fetal growth and accelerated growth during childhood. They are dissimilar, however, in that insulin resistance is associated with thinness in childhood and low maternal BMI, while Type II diabetes is associated with high BMI in childhood and high maternal BMI.

Item Type: Article
ISSNs: 0012-186X (print)
Related URLs:
Keywords: fetal growth, childhood growth, maternal weight, insulin resistance, type ii diabetes
Subjects: R Medicine > RB Pathology
Q Science > QP Physiology
R Medicine > RA Public aspects of medicine
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25468
Date Deposited: 12 Apr 2006
Last Modified: 27 Mar 2014 18:14
Contact Email Address: co@mrc.soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/25468

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