The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-?2 gene on insulin sensitivity and insulin metabolism interact with size at birth
Eriksson, Johan G., Lindi, Virpi, Uusitupa, Matti, Forsen, Tom J., Laakso, Markku, Osmond, Clive and Barker, David J. P. (2002) The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-?2 gene on insulin sensitivity and insulin metabolism interact with size at birth. Diabetes, 51, (7), 2321-2324.
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Type 2 diabetes is known to be associated with a small body size at birth. Body size at birth is an indicator of the intrauterine environment. There is also a well-established association between the peroxisome proliferator-activated receptor (PPAR)-?2 gene and type 2 diabetes. We therefore assessed whether the effects of the Pro12Ala polymorphism of the PPAR-?2 gene on insulin sensitivity and insulin concentrations in adult life are modified by size at birth. We found that the effects of the Pro12Pro and Pro12Ala polymorphisms of the PPAR-?2 gene in elderly people depended on their body size at birth. The well-known association between small body size at birth and insulin resistance was seen only in individuals with the high-risk Pro12Pro allele. In those who had low birth weight, the Pro12Pro polymorphism of the PPAR-?2 gene was associated with increased insulin resistance (P < 0.002) and elevated insulin concentrations (P < 0.003). These interactions between the effects of the Pro12Ala polymorphisms of the PPAR-?2 gene on adult traits and the effects of birth weight link two previously unknown associations together within the context of type 2 diabetes. We suggest that these findings reflect gene-environment interaction.
|Additional Information:||Brief Genetics Report|
|Subjects:||R Medicine > RB Pathology
Q Science > QP Physiology
Q Science > QH Natural history > QH426 Genetics
|Divisions :||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Accepted Date and Publication Date:||
|Date Deposited:||12 Apr 2006|
|Last Modified:||31 Mar 2016 11:47|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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