The University of Southampton
University of Southampton Institutional Repository

Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans

Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans
Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans
Dietary ?-linolenic acid (ALA) can be converted to long-chain (n-3) PUFA in humans and may potentially reproduce the beneficial effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids on risk factors for coronary heart disease (CHD). This study compared the effects of increased intakes of ALA with those of dietary EPA and DHA on blood coagulation and fibrinolytic factors in fasting subjects. A placebo-controlled, parallel study was conducted in 150 moderately hyperlipidemic subjects, age 25–72 y. Subjects were randomly assigned to one of five interventions and consumed a total intake of 0.8 or 1.7g/d EPA+DHA, 4.5 or 9.5g/d ALA or control (linoleic acid; LA) for 6 mo. Fatty acids were incorporated into 25 g of fat spread, which replaced the subject’s normal spread and three capsules. Long-term supplementation with either dietary EPA+DHA or estimated biologically equivalent amounts of ALA did not affect factors VIIa, VIIc, VIIag, XIIa, XIIag, fibrinogen concentrations, plasminogen activator inhibitor-1 or tissue plasminogen activator activity compared with the control. (n-3) PUFA of plant or marine origin do not differ from one another or from LA in their effect on a range of blood coagulation and fibrinolytic factors.
?-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, factor viic, factor xii
0022-3166
2210-2213
Finnegan, Yvonne E.
55946247-9cb4-4562-b11b-30e410669aac
Howarth, David
71901628-d8cb-499b-9cdd-871fe5bb1b4f
Minihane, Anne M.
323fcab6-215c-4c13-b8d4-2ad242a31900
Kew, Samantha
0388d70a-7691-4660-9896-95a45099a5db
Miller, George J.
d8e958dd-7ba2-4c1f-88c9-7d8c99747933
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Williams, Christine M.
4cf5b7be-8973-4ed3-9150-5caf74999670
Finnegan, Yvonne E.
55946247-9cb4-4562-b11b-30e410669aac
Howarth, David
71901628-d8cb-499b-9cdd-871fe5bb1b4f
Minihane, Anne M.
323fcab6-215c-4c13-b8d4-2ad242a31900
Kew, Samantha
0388d70a-7691-4660-9896-95a45099a5db
Miller, George J.
d8e958dd-7ba2-4c1f-88c9-7d8c99747933
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Williams, Christine M.
4cf5b7be-8973-4ed3-9150-5caf74999670

Finnegan, Yvonne E., Howarth, David, Minihane, Anne M., Kew, Samantha, Miller, George J., Calder, Philip C. and Williams, Christine M. (2003) Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. Journal of Nutrition, 133 (7), 2210-2213.

Record type: Article

Abstract

Dietary ?-linolenic acid (ALA) can be converted to long-chain (n-3) PUFA in humans and may potentially reproduce the beneficial effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids on risk factors for coronary heart disease (CHD). This study compared the effects of increased intakes of ALA with those of dietary EPA and DHA on blood coagulation and fibrinolytic factors in fasting subjects. A placebo-controlled, parallel study was conducted in 150 moderately hyperlipidemic subjects, age 25–72 y. Subjects were randomly assigned to one of five interventions and consumed a total intake of 0.8 or 1.7g/d EPA+DHA, 4.5 or 9.5g/d ALA or control (linoleic acid; LA) for 6 mo. Fatty acids were incorporated into 25 g of fat spread, which replaced the subject’s normal spread and three capsules. Long-term supplementation with either dietary EPA+DHA or estimated biologically equivalent amounts of ALA did not affect factors VIIa, VIIc, VIIag, XIIa, XIIag, fibrinogen concentrations, plasminogen activator inhibitor-1 or tissue plasminogen activator activity compared with the control. (n-3) PUFA of plant or marine origin do not differ from one another or from LA in their effect on a range of blood coagulation and fibrinolytic factors.

This record has no associated files available for download.

More information

Published date: 2003
Keywords: ?-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, factor viic, factor xii

Identifiers

Local EPrints ID: 25489
URI: http://eprints.soton.ac.uk/id/eprint/25489
ISSN: 0022-3166
PURE UUID: 1f79d994-c3cf-4b53-91fb-117826c79c6d
ORCID for Philip C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 19 Apr 2006
Last modified: 23 Jul 2022 01:39

Export record

Contributors

Author: Yvonne E. Finnegan
Author: David Howarth
Author: Anne M. Minihane
Author: Samantha Kew
Author: George J. Miller
Author: Christine M. Williams

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×