Birth weight and later risk of depression in a national birth cohort
Birth weight and later risk of depression in a national birth cohort
Background: Low birth weight increases the risk of childhood behavioural problems, but it is not clear whether poor foetal growth has a long-term influence on susceptibility to depression.
Aims:To examine the relation between birth weight and risk of psychological distress and depression.
Method: At age 16 years 5187 participants in the 1970 British Cohort Study completed the 12-item General Health Questionnaire to assess psychological distress. At age 26 years 8292 participants completed the Malaise Inventory to assess depression and provided information about a history of depression.
Results: Women whose birth weight was 3 kg had an increased risk of depression at age 26 years (OR=1.3; 95% CI1.0–1.5) compared with those who weighed >3.5 kg. Birth weight was not associated with a reported history of depression or with risk of psychological distress at age 16 years. In men there were no associations between any measurement and the full range of birth weight but, compared with men of normal birth weight, those born weighing 2.5 kg were more likely to be psychologically distressed at age 16 years (OR=1.6,95% CI1.1–2.5) and to report a history of depression at age 26 years (OR=1.6,95% CI1.1–2.3).
Conclusions: Impaired neurodevelopment during foetal life may increase susceptibility to depression.
28-33
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Martyn, Christopher N.
eb9a7811-3550-4586-9aca-795f2ad05090
2004
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Martyn, Christopher N.
eb9a7811-3550-4586-9aca-795f2ad05090
Gale, Catharine R. and Martyn, Christopher N.
(2004)
Birth weight and later risk of depression in a national birth cohort.
British Journal of Psychiatry, 184, .
Abstract
Background: Low birth weight increases the risk of childhood behavioural problems, but it is not clear whether poor foetal growth has a long-term influence on susceptibility to depression.
Aims:To examine the relation between birth weight and risk of psychological distress and depression.
Method: At age 16 years 5187 participants in the 1970 British Cohort Study completed the 12-item General Health Questionnaire to assess psychological distress. At age 26 years 8292 participants completed the Malaise Inventory to assess depression and provided information about a history of depression.
Results: Women whose birth weight was 3 kg had an increased risk of depression at age 26 years (OR=1.3; 95% CI1.0–1.5) compared with those who weighed >3.5 kg. Birth weight was not associated with a reported history of depression or with risk of psychological distress at age 16 years. In men there were no associations between any measurement and the full range of birth weight but, compared with men of normal birth weight, those born weighing 2.5 kg were more likely to be psychologically distressed at age 16 years (OR=1.6,95% CI1.1–2.5) and to report a history of depression at age 26 years (OR=1.6,95% CI1.1–2.3).
Conclusions: Impaired neurodevelopment during foetal life may increase susceptibility to depression.
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Published date: 2004
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Local EPrints ID: 25521
URI: http://eprints.soton.ac.uk/id/eprint/25521
ISSN: 0007-1250
PURE UUID: 6b1c6794-032f-4912-8b29-782f7278e78b
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Date deposited: 11 Apr 2006
Last modified: 08 Jan 2022 02:42
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Author:
Christopher N. Martyn
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